Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients

被引：15
作者：
de Souza Tesch, R. [1 ]
Ladeira Bonato, L. [2 ]
Quinelato, V [2 ]
Ladeira Casado, P. [2 ]
Rezende Vieira, A. [3 ]
Granjeiro, J. M. [4 ]
Goes, C. [5 ]
机构：
[1] Sch Med Petropolis, Barao do Rio Branco Av 1003, BR-85900005 Petropolis, RJ, Brazil
[2] Fluminense Fed Univ, Niteroi, RJ, Brazil
[3] Univ Pittsburgh, Sch Dent Med, Pittsburgh, PA USA
[4] Natl Inst Metrol Qual & Technol, Rio De Janeiro, Brazil
[5] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil
来源：
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2020年 / 49卷 / 02期
关键词：
chronic pain; temporomandibular joint dysfunction syndrome; pain; genetic polymorphism; CHRONIC PAIN; DEPENDENT PAIN; FIBROMYALGIA; POPULATION; EXPRESSION; WOMEN;
D O I：
10.1016/j.ijom.2019.06.027
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The aim of this study was to evaluate the possible association between polymorphisms in the catechol-O- methyltransferase (COMT) and beta 2-adrenergic receptor (ADRB2) genes and muscular temporomandibular disorders (TMD). This was a case-control study. Individuals were evaluated using the Research Diagnostic Criteria for Temporomandibular Disorders and were divided into three groups: unaffected (no TMD) (n = 154); exclusively muscular TMD (n = 49); exclusively articular TMD (n = 49). Genomic DNA was obtained from saliva samples, and single nucleotide polymorphisms in the COMT (rs165774, rs6269, rs9332377) and ADRB2 ( rs2053044, rs1042713, rs1042714) genes were investigated. The TT genotype for the COMT rs9332377 gene was highly associated with the presence of muscular TMD (P = 0.03). With respect to the ADRB2 gene, the non-polymorphic AA genotype in the rs1042713 region was more prevalent in the articular TMD group than in the muscular TMD group (P = 0.05). This study supports the hypothesis that alterations in the COMT and ADRB2 genes influence the muscular pathophysiology.
引用
收藏
页码：237 / 243
页数：7
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