Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients

被引：15

作者：

de Souza Tesch, R. ^{[1
]}

Ladeira Bonato, L. ^{[2
]}

Quinelato, V ^{[2
]}

Ladeira Casado, P. ^{[2
]}

Rezende Vieira, A. ^{[3
]}

Granjeiro, J. M. ^{[4
]}

Goes, C. ^{[5
]}

机构：

[1] Sch Med Petropolis, Barao do Rio Branco Av 1003, BR-85900005 Petropolis, RJ, Brazil

[2] Fluminense Fed Univ, Niteroi, RJ, Brazil

[3] Univ Pittsburgh, Sch Dent Med, Pittsburgh, PA USA

[4] Natl Inst Metrol Qual & Technol, Rio De Janeiro, Brazil

[5] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2020年 / 49卷 / 02期

关键词：

chronic pain; temporomandibular joint dysfunction syndrome; pain; genetic polymorphism; CHRONIC PAIN; DEPENDENT PAIN; FIBROMYALGIA; POPULATION; EXPRESSION; WOMEN;

D O I：

10.1016/j.ijom.2019.06.027

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The aim of this study was to evaluate the possible association between polymorphisms in the catechol-O- methyltransferase (COMT) and beta 2-adrenergic receptor (ADRB2) genes and muscular temporomandibular disorders (TMD). This was a case-control study. Individuals were evaluated using the Research Diagnostic Criteria for Temporomandibular Disorders and were divided into three groups: unaffected (no TMD) (n = 154); exclusively muscular TMD (n = 49); exclusively articular TMD (n = 49). Genomic DNA was obtained from saliva samples, and single nucleotide polymorphisms in the COMT (rs165774, rs6269, rs9332377) and ADRB2 ( rs2053044, rs1042713, rs1042714) genes were investigated. The TT genotype for the COMT rs9332377 gene was highly associated with the presence of muscular TMD (P = 0.03). With respect to the ADRB2 gene, the non-polymorphic AA genotype in the rs1042713 region was more prevalent in the articular TMD group than in the muscular TMD group (P = 0.05). This study supports the hypothesis that alterations in the COMT and ADRB2 genes influence the muscular pathophysiology.

引用

页码：237 / 243

页数：7

共 30 条

[1] TMD before and after correction of dentofacial deformities by orthodontic and orthognathic treatment [J].

Abrahamsson, C. ;

Henrikson, T. ;

Nilner, M. ;

Sunzel, B. ;

Bondemark, L. ;

Ekberg, E. C. .

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2013, 42 (06) :752-758

[2] Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study [J].

Bair, Eric ;

Gaynor, Sheila ;

Slade, Gary D. ;

Ohrbach, Richard ;

Fillingim, Roger B. ;

Greenspan, Joel D. ;

Dubner, Ronald ;

Smith, Shad B. ;

Diatchenko, Luda ;

Maixner, William .

PAIN, 2016, 157 (06) :1266-1278

[3] Pain modality- and sex-specific effects of COMT genetic functional variants [J].

Belfer, Inna ;

Segall, Samantha K. ;

Lariviere, William R. ;

Smith, Shad B. ;

Dai, Feng ;

Slade, Gary D. ;

Rashid, Naim U. ;

Mogil, Jeffrey S. ;

Campbell, Claudia M. ;

Edwards, Robert R. ;

Liu, Qian ;

Bair, Eric ;

Maixner, William ;

Diatchenko, Luda .

PAIN, 2013, 154 (08) :1368-1376

[4] Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic Receptors [J].

Ciszek, Brittney P. ;

O'Buckley, Sandra C. ;

Nackley, Andrea G. .

ANESTHESIOLOGY, 2016, 124 (05) :1122-1135

[5] Genetic basis for individual variations in pain perception and the development of a chronic pain condition [J].

Diatchenko, L ;

Slade, GD ;

Nackley, AG ;

Bhalang, K ;

Sigurdsson, A ;

Belfer, I ;

Goldman, D ;

Xu, K ;

Shabalina, SA ;

Shagin, D ;

Max, MB ;

Makarov, SS ;

Maixner, W .

HUMAN MOLECULAR GENETICS, 2005, 14 (01) :135-143

[6] Three major haplotypes of the β2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder [J].

Diatchenko, Luda ;

Anderson, Amy D. ;

Slade, Gary D. ;

Fillingim, Roger B. ;

Shabalina, Svetlana A. ;

Higgins, Tomas J. ;

Sama, Swetha ;

Inna, Belfer ;

Goldman, David ;

Max, Mitchell B. ;

Weir, Bruce S. ;

Maixner, William .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (05) :449-462

[7]

Dworkin Samuel F., 1992, Journal of Craniomandibular Disorders, V6, P301

[8] Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery [J].

Eshragh, Jasmine ;

Dhruva, Anand ;

Paul, Steven M. ;

Cooper, Bruce A. ;

Mastick, Judy ;

Hamolsky, Deborah ;

Levine, Jon D. ;

Miaskowski, Christine ;

Kober, Kord M. .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2017, 53 (01) :67-U200

[9] BIOCHEMICAL MEASURE OF STRESS IN PATIENTS WITH MYOFASCIAL PAIN-DYSFUNCTION SYNDROME [J].

EVASKUS, DS ;

LASKIN, DM .

JOURNAL OF DENTAL RESEARCH, 1972, 51 (05) :1464-&

[10]

Furquim Bruno D'Aurea, 2015, Dental Press J. Orthod., V20, P127, DOI 10.1590/2176-9451.20.1.127-133.sar

← 1 2 3 →