Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents

被引：6

作者：

Kudale, Sayali D. ^{[1
]}

Deodhar, Meenakshi N. ^{[1
]}

机构：

[1] Sable Coll Pharm, Dept Pharmaceut Chem, Pune 412301, Maharashtra, India

来源：

E-JOURNAL OF CHEMISTRY | 2012年 / 9卷 / 04期

关键词：

Coumarins; Chalcone; Schiff's base; Antibacterial; Antifungal activity;

D O I：

10.1155/2012/953564

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aseries of the Schiff's bases incorporating coumarin and chalcone moeities, 3-(4-(4-(substituted phenyl) prop-1-ene-3-one) phenylimino) methyl)4- chloro-2h-chromen-2-one 4(a-g) were synthesized as potential antimicrobial agents. These compounds were characterized on the basis of their spectral (IR, H-1 NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 4b was found to be most active with an MIC of 20 mu g/mL against all the tested organisms.

引用

页码：2493 / 2500

页数：8

共 13 条

[1] Bimetallic complexes of Schiff base bis-[4-hydroxycuomarin-3-yl]-1N,5N-thiocarbohydrazone as a potentially dibasic pentadentate ligand.: Synthesis, spectral, and antimicrobial properties [J].

Abou-Melha, K. S. ;

Faruk, H. .

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2008, 5 (01) :122-134

[2] Design, Synthesis and Evaluation of Schiff's Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents [J].

Bairagi, Shriram ;

Bhosale, Ashok ;

Deodhar, Meenakshi N. .

E-JOURNAL OF CHEMISTRY, 2009, 6 (03) :759-762

[3]

BERNADETTE SC, 2006, INORG CHIM ACTA, V359, P3976

[4]

Braccio M D., 2004, Eur.J.Med.Chem, V39, P337

[5] THE PREPARATION OF 2-THIOPHENEALDEHYDE AND SOME OF ITS DERIVATIVES [J].

EMERSON, WS ;

PATRICK, TM .

JOURNAL OF ORGANIC CHEMISTRY, 1949, 14 (05) :790-797

[6]

Hugo W, 1987, PHARM MICROBIOL, V4, P265

[7]

Kaufmann W, 1923, J AM CHEM SOC, V45, P1839

[8]

Kokare C, 2007, PHARM MICROBIOLOGY E, V2, P139

[9] Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B [J].

Laurin, P ;

Ferroud, D ;

Klich, M ;

Dupuis-Hamelin, C ;

Mauvais, P ;

Lassaigne, P ;

Bonnefoy, A ;

Musicki, B .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (14) :2079-2084

[10]

Pophale R, PHARM CHEM, V2, P185

← 1 2 →