Synthesis and antimicrobial properties of cyclic fluorodiamines containing boronate esters

被引：5

作者：

Zhu, Diya ^{[1
]}

Hunter, Carmanah D. ^{[1
]}

Baird, Samuel R. ^{[1
]}

Davis, Bradley R. ^{[2
]}

Bos, Allyson ^{[2
]}

Geier, Stephen J. ^{[1
]}

Vogels, Christopher M. ^{[1
]}

Decken, Andreas ^{[3
]}

Gray, Christopher A. ^{[2
,3
]}

Westcott, Stephen A. ^{[1
]}

机构：

[1] Mt Allison Univ, Dept Chem & Biochem, Sackville, NB, Canada

[2] Univ New Brunswick, Dept Biol, St John, NB, Canada

[3] Univ New Brunswick, Dept Chem, Fredericton, NB, Canada

来源：

HETEROATOM CHEMISTRY | 2017年 / 28卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

antimicrobial; bioactivity; boron; boronate ester; fluorine; COMPLEXES; BENZOXABOROLES; FLUORINE; LIGANDS;

D O I：

10.1002/hc.21405

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eight new aminoboron compounds derived from primary diamines and the pinacol-protected product of 3-fluoro-2-formylphenylboronic acid have been prepared and characterized fully. Reactions proceed to give the corresponding cyclic products arising via initial aldimine formation followed by a secondary hydroamination step. One compound contains a pendant amine group which was used to make a novel boron-containing Schiff base ligand along with the corresponding zinc(II) metal complex. All compounds were tested for their initial antimicrobial activities against a number of fungi and bacteria.

引用

页数：11

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