Hemogenic endothelium during development and beyond

被引：79

作者：

Hirschi, Karen K. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Yale Stem Cell Ctr, Yale Cardiovasc Res Ctr, New Haven, CT 06511 USA

来源：

BLOOD | 2012年 / 119卷 / 21期

关键词：

HEMATOPOIETIC STEM-CELLS; MOUSE EMBRYO; DEFINITIVE HEMATOPOIESIS; SERIAL TRANSPLANTATION; YOLK-SAC; AORTIC ENDOTHELIUM; PROGENITOR CELLS; VASCULAR NICHE; RETINOIC ACID; BLOOD-VESSELS;

D O I：

10.1182/blood-2011-12-353466

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During embryonic development, multi-lineage HSCs/progenitor cells are derived from specialized endothelial cells, termed hemogenic endothelium, within the yolk sac, placenta, and aorta. Whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known. Also unknown is whether such cells exist within the vasculature of adult bone marrow and generate hematopoietic stem cells after birth. These issues and their clinical relevance are discussed herein. (Blood. 2012;119(21):4823-4827)

引用

页码：4823 / 4827

页数：5

共 50 条

[21] Retinoic acid regulates endothelial cell proliferation during vasculogenesis [J].

Lai, LH ;

Bohnsack, BL ;

Niederreither, K ;

Hirschi, KK .

DEVELOPMENT, 2003, 130 (26) :6465-6474

[22] The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage [J].

Lancrin, Christophe ;

Sroczynska, Patrycja ;

Stephenson, Catherine ;

Allen, Terry ;

Kouskoff, Valerie ;

Lacaud, Georges .

NATURE, 2009, 457 (7231) :892-895

[23] Bone marrow sinusoidal endothelial cells undergo nonapoptotic cell death and are replaced by proliferating sinusoidal cells in situ to maintain the vascular niche following lethal irradiation [J].

Li, Xiao-Miao ;

Hu, Zhongbo ;

Jorgenson, Marda L. ;

Wingard, John R. ;

Slayton, William B. .

EXPERIMENTAL HEMATOLOGY, 2008, 36 (09) :1143-1156

[24] Vascular remodeling of the mouse yolk sac requires hemodynamic force [J].

Lucitti, Jennifer L. ;

Jones, Elizabeth A. V. ;

Huang, Chengqun ;

Chen, Ju ;

Fraser, Scott E. ;

Dickinson, Mary E. .

DEVELOPMENT, 2007, 134 (18) :3317-3326

[25] Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration [J].

Majka, SM ;

Jackson, KA ;

Kienstra, KA ;

Majesky, MW ;

Goodell, MA ;

Hirschi, KK .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (01) :71-79

[26] Definitive hematopoiesis is autonomously initiated by the AGM region [J].

Medvinsky, A ;

Dzierzak, E .

CELL, 1996, 86 (06) :897-906

[27] Embryonic origin of the adult hematopoietic system: advances and questions [J].

Medvinsky, Alexander ;

Rybtsov, Stanislav ;

Taoudi, Samir .

DEVELOPMENT, 2011, 138 (06) :1017-1031

[28] Evidence for novel fate of Flk1+ progenitor:: Contribution to muscle lineage [J].

Motoike, T ;

Markham, DW ;

Rossant, J ;

Sato, TN .

GENESIS, 2003, 35 (03) :153-159

[29] DEVELOPMENT OF HEMATOPOIETIC STEM-CELL ACTIVITY IN THE MOUSE EMBRYO [J].

MULLER, AM ;

MEDVINSKY, A ;

STROUBOULIS, J ;

GROSVELD, F ;

DZIERZAK, E .

IMMUNITY, 1994, 1 (04) :291-301

[30]

MURRAY PDF, 1932, P R SOC LOND, V11, P497

← 1 2 3 4 5 →