Hemogenic endothelium during development and beyond

被引：79
作者：
Hirschi, Karen K. [1 ]
机构：
[1] Yale Univ, Sch Med, Yale Stem Cell Ctr, Yale Cardiovasc Res Ctr, New Haven, CT 06511 USA
来源：
BLOOD | 2012年 / 119卷 / 21期
关键词：
HEMATOPOIETIC STEM-CELLS; MOUSE EMBRYO; DEFINITIVE HEMATOPOIESIS; SERIAL TRANSPLANTATION; YOLK-SAC; AORTIC ENDOTHELIUM; PROGENITOR CELLS; VASCULAR NICHE; RETINOIC ACID; BLOOD-VESSELS;
D O I：
10.1182/blood-2011-12-353466
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
During embryonic development, multi-lineage HSCs/progenitor cells are derived from specialized endothelial cells, termed hemogenic endothelium, within the yolk sac, placenta, and aorta. Whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known. Also unknown is whether such cells exist within the vasculature of adult bone marrow and generate hematopoietic stem cells after birth. These issues and their clinical relevance are discussed herein. (Blood. 2012;119(21):4823-4827)
引用
收藏
页码：4823 / 4827
页数：5
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