Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles-A Systematic Review

被引：25

作者：

Rolo, Dora ^{[1
,2
]}

Assuncao, Ricardo ^{[1
,3
,4
]}

Ventura, Celia ^{[1
,2
]}

Alvito, Paula ^{[1
,3
]}

Goncalves, Lidia ^{[5
]}

Martins, Carla ^{[1
,6
,7
]}

Bettencourt, Ana ^{[5
]}

Jordan, Peter ^{[1
,8
]}

Vital, Nadia ^{[1
,2
,9
]}

Pereira, Joana ^{[1
,8
]}

Pinto, Fatima ^{[1
,2
]}

Matos, Paulo ^{[1
,8
]}

Silva, Maria Joao ^{[1
,2
]}

Louro, Henriqueta ^{[1
,2
]}

机构：

[1] Natl Inst Hlth Dr Ricardo Jorge, P-1649016 Lisbon, Portugal

[2] Univ NOVA Lisboa, Tox Ctr Toxicogen & Human Hlth, NOVA Med Sch, P-1169056 Lisbon, Portugal

[3] Univ Aveiro, Ctr Environm & Marine Studies, CESAM, P-3810193 Aveiro, Portugal

[4] Inst Univ Egas Moniz, CRL, Egas Moniz Cooperat Ensino Super, IUEM, P-2829511 Monte De Caparica, Portugal

[5] Univ Lisbon, Fac Pharm, Res Inst Med iMedULisboa, P-1649003 Lisbon, Portugal

[6] Univ NOVA Lisboa, Publ Hlth Res Ctr, NOVA Natl Sch Publ Hlth, P-1600560 Lisbon, Portugal

[7] Comprehens Hlth Res Ctr CHRC, P-1169056 Lisbon, Portugal

[8] Univ Lisbon, Fac Sci, BioISI Biosyst & Integrat Sci Inst, P-1749016 Lisbon, Portugal

[9] Univ NOVA Lisboa, NOVA Med Sch, P-1169056 Lisbon, Portugal

来源：

NANOMATERIALS | 2022年 / 12卷 / 19期

关键词：

titanium dioxide nanoparticles; human exposure; ingested TIO2-NPs; AOP; nanosafety; colorectal cancer; adverse outcomes; METAL-OXIDE NANOPARTICLES; POSSIBLE PROTECTIVE ROLE; FOOD ADDITIVE E171; IN-VITRO; TIO2; NANOPARTICLES; OXIDATIVE STRESS; ORAL-EXPOSURE; PLASMA-GLUCOSE; MATERNAL EXPOSURE; DNA-DAMAGE;

D O I：

10.3390/nano12193275

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Titanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integrative analysis of the published data on cellular and molecular mechanisms triggered after the ingestion of TiO2-NPs, proposing plausible AOPs that may drive policy decisions. A systematic review according to Prisma Methodology was performed in three databases of peer-reviewed literature: Pubmed, Scopus, and Web of Science. A total of 787 records were identified, screened in title/abstract, being 185 used for data extraction. The main endpoints identified were oxidative stress, cytotoxicity/apoptosis/cell death, inflammation, cellular and systemic uptake, genotoxicity, and carcinogenicity. From the results, AOPs were proposed where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. The recent transgenerational studies also point to concerns with regard to population effects. Overall, the findings further support a limitation of the use of TiO2-NPs in food, announced by the European Food Safety Authority (EFSA).

引用

页数：32

共 237 条

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