Enantioselective C(sp3)-H Amidation of Thioamides Catalyzed by a CobaltIII/Chiral Carboxylic Acid Hybrid System

被引：205

作者：

Fukagawa, Seiya ^{[1
]}

Kato, Yoshimi ^{[1
]}

Tanaka, Ryo ^{[1
]}

Kojima, Masahiro ^{[1
]}

Yoshino, Tatsuhiko ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 04期

关键词：

asymmetric catalysis; C-H activation; chiral carboxylic acids; cobalt; thioamide; C-H ACTIVATION; CHIRAL CYCLOPENTADIENYL LIGANDS; INTERMOLECULAR AMINATION; SELECTIVE FUNCTIONALIZATION; BIARYL COMPOUNDS; BONDS; ALKYLAMINES; ACCESS; COMPLEXES; MECHANISM;

D O I：

10.1002/anie.201812215

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent advances in (CpMIII)-M-x catalysis (M=Co, Rh, Ir) have enabled a variety of enantioselective C(sp(2))-H functionalization reactions, but enantioselective C(sp(3))-H functionalization is still largely unexplored. We describe an asymmetric C(sp(3))-H amidation of thioamides using an achiral Co-III/chiral carboxylic acid hybrid catalytic system, which provides easy and straightforward access to chiral beta-amino thiocarbonyl and beta-amino carbonyl building blocks with a quaternary carbon stereocenter.

引用

页码：1153 / 1157

页数：5

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