Unfolded protein response in cardiovascular disease

被引：29

作者：

Kubra, Khadeja-Tul ^{[1
]}

Akhter, Mohammad S. ^{[1
]}

Uddin, Mohammad A. ^{[1
]}

Barabutis, Nektarios ^{[1
]}

机构：

[1] Univ Louisiana Monroe, Coll Pharm, Sch Basic Pharmaceut & Toxicol Sci, Monroe, LA 71201 USA

来源：

CELLULAR SIGNALLING | 2020年 / 73卷

关键词：

ER stress; Cardiac hypertrophy; Myocardial infarction; Arrhythmia; ENDOPLASMIC-RETICULUM STRESS; ENDOTHELIAL BARRIER FUNCTION; TRANSIENT CEREBRAL-ISCHEMIA; C/EBP HOMOLOGOUS PROTEIN; OXIDATIVE STRESS; BRAIN ISCHEMIA; HEART-FAILURE; ER STRESS; TRANSMEMBRANE PROTEIN; MYOCARDIAL-INFARCTION;

D O I：

10.1016/j.cellsig.2020.109699

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The unfolded protein response (UPR) is a highly conserved molecular machinery, which protects the cells against a diverse variety of stimuli. Activation of this element has been associated with both human health and disease. The purpose of the current manuscript is to provide the most updated information on the involvement of UPR towards the improvement; or deterioration of cardiovascular functions. Since UPR is consisted of three distinct elements, namely the activating transcription factor 6, the protein kinase RNA-like endoplasmic reticulum kinase; and the inositol-requiring enzyme-1 alpha, a highly orchestrated manipulation of those molecular branches may provide new therapeutic possibilities against the severe outcomes of cardiovascular disease.

引用

页数：6

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