Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes

被引：82

作者：

Yamada, Hodaka ^{[1
]}

Saito, Tomoyuki ^{[1
]}

Aoki, Atsushi ^{[1
]}

Asano, Tomoko ^{[1
]}

Yoshida, Masashi ^{[1
]}

Ikoma, Aki ^{[1
]}

Kusaka, Ikuyo ^{[1
]}

Toyoshima, Hideo ^{[1
]}

Kakei, Masafumi ^{[1
]}

Ishikawa, San-e ^{[1
]}

机构：

[1] Jichi Med Univ, Saitama Med Ctr, Div Endocrinol & Metab, Saitama 3308503, Japan

来源：

ENDOCRINE JOURNAL | 2015年 / 62卷 / 05期

基金：

日本学术振兴会;

关键词：

Betatrophin; Beta cells proliferation; Insulin resistance; Lipid metabolism; PANCREATIC BETA-CELL; ANGIOPOIETIN-LIKE PROTEIN; LIPASIN; GLUCOSE; METABOLISM;

D O I：

10.1507/endocrj.EJ14-0525

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is evidence that betatrophin, a hormone derived from adipose tissue and liver, affects the proliferation of pancreatic beta cells in mice. The aim of this study was to examine circulating betatrophin concentrations in Japanese healthy controls and patients with type 1 and type 2 diabetes. A total of 76 subjects (12 healthy controls, 34 type 1 diabetes, 30 type 2 diabetes) were enrolled in the study. Circulating betatrophin was measured with an ELISA kit and clinical parameters related to betatrophin were analyzed statistically. Circulating betatrophin (Log transformed) was significantly increased in patients with diabetes compared with healthy subjects (healthy controls, 2.29 +/- 0.51; type 1 diabetes, 2.94 +/- 0.44; type 2 diabetes, 3.17 +/- 0.18; p<0.001, 4.1 to 5.4 times in pg/mL order). Age, HbA1c, fasting plasma glucose and Log triglyceride were strongly associated with Log betatrophin in all subjects (n=76) in correlation analysis. In type 1 diabetes, there was a correlation between Log betatrophin and Log CPR. These results provide the first evidence that circulating betatrophin is significantly elevated in Japanese patients with diabetes. The findings of this pilot study also suggest a possibility of association between the level of betatrophin and the levels of glucose and triglycerides.

引用

页码：417 / 421

页数：5

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