Management of chronic hepatitis B: an update

被引：6
作者：
Negro, Francesco [1 ,2 ]
机构：
[1] Univ Hosp Geneva, Div Gastroenterol & Hepatol, CH-1211 Geneva 14, Switzerland
[2] Univ Hosp Geneva, Div Clin Pathol, CH-1211 Geneva 14, Switzerland
来源：
SWISS MEDICAL WEEKLY | 2011年 / 141卷
关键词：
hepatitis B virus; chronic hepatitis B; tenofovir; entecavir; cirrhosis; DISOPROXIL FUMARATE TDF; INDUCED HBEAG SEROCONVERSION; TERM-FOLLOW-UP; SURFACE-ANTIGEN; PEGINTERFERON ALPHA-2A; SUSTAINED RESPONSE; NATURAL-HISTORY; HBSAG KINETICS; HBV INFECTION; ENTECAVIR;
D O I：
10.4414/smw.2011.13264
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Since the publication in 2009 of clinical practice guidelines for the management of hepatitis B virus (HBV) infection by the European Association for the Study of the Liver (EASL), a wealth of new data has emerged regarding the antivirals most commonly used to treat chronic hepatitis B. This review will summarise the most recent knowledge on these drugs, and how this may affect current and future management of HBV infection. Despite the progress in drug development, HBV infection remains a complex entity, characterised by a peculiar interplay between host and viral factors. With the potent drugs currently available, however, its management and control are possible in the majority of cases.
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页数：7
相关论文
共 58 条
[1]  
[Anonymous], [No title captured]
[2]  
Bart PA, 1996, LIVER, V16, P110
[3]  
BELLONI L, J CLIN INVE IN PRESS
[4]   Tenofovir Is Effective Alone or With Emtricitabine in Adefovir-Treated Patients With Chronic-Hepatitis B Virus Infection [J].
Berg, Thomas ;
Marcellin, Patrick ;
Zoulim, Fabien ;
Moller, Bernd ;
Trinh, Huy ;
Chan, Sing ;
Suarez, Emilio ;
Lavocat, Fabien ;
Snow-Lampart, Andrea ;
Frederick, David ;
Sorbel, Jeff ;
Borroto-Esoda, Katyna ;
Oldach, David ;
Rousseau, Franck .
GASTROENTEROLOGY, 2010, 139 (04) :1207-+
[5]  
Bihl F, 2010, SWISS MED WKLY, V140, P154, DOI smw-12969
[6]   Hepatitis B Surface Antigen Serum Levels Help to Distinguish Active From Inactive Hepatitis B Virus Genotype D Carriers [J].
Brunetto, Maurizia Rossana ;
Oliveri, Filippo ;
Colombatto, Piero ;
Moriconi, Francesco ;
Ciccorossi, Pietro ;
Coco, Barbara ;
Romagnoli, Veronica ;
Cherubini, Beatrice ;
Moscato, Giovanna ;
Maina, Anna Maria ;
Cavallone, Daniela ;
Bonino, Ferruccio .
GASTROENTEROLOGY, 2010, 139 (02) :483-490
[7]   Hepatitis B Virus Surface Antigen Levels: A Guide to Sustained Response to peginterferon alfa-2a in HBeAg-Negative Chronic Hepatitis B [J].
Brunetto, Maurizia Rossana ;
Moriconi, Francesco ;
Bonino, Ferruccio ;
Lau, George K. K. ;
Farci, Patrizia ;
Yurdaydin, Cihan ;
Piratvisuth, Teerha ;
Luo, Kanxian ;
Wang, Yuming ;
Hadziyannis, Stephanos ;
Wolf, Eva ;
McCloud, Philip ;
Batrla, Richard ;
Marcellin, Patrick .
HEPATOLOGY, 2009, 49 (04) :1141-1150
[8]   Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon α-2b [J].
Buster, Erik H. C. J. ;
Flink, Hajo J. ;
Cakaloglu, Yilmaz ;
Simon, Krzysztof ;
Trojan, Joerg ;
Tabak, Fehmi ;
So, Thomas M. K. ;
Feinman, S. Victor ;
Mach, Tomasz ;
Akarca, Ulus S. ;
Schutten, Martin ;
Tielemans, Wanda ;
van Vuuren, Anneke J. ;
Hansen, Bettina E. ;
Janssen, Harry L. A. .
GASTROENTEROLOGY, 2008, 135 (02) :459-467
[9]   Factors That Predict Response of Patients With Hepatitis B e Antigen-Positive Chronic Hepatitis B to Peginterferon-Alfa [J].
Buster, Erik H. C. J. ;
Hansen, Bettina E. ;
Lau, George K. K. ;
Piratvisuth, Teerha ;
Zeuzem, Stefan ;
Steyerberg, Ewout W. ;
Janssen, Harry L. A. .
GASTROENTEROLOGY, 2009, 137 (06) :2002-2009
[10]   Entecavir Treatment for up to 5 Years in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B [J].
Chang, Ting-Tsung ;
Lai, Ching-Lung ;
Yoon, Seung Kew ;
Lee, Samuel S. ;
Coelho, Henrique Sergio M. ;
Carrilho, Flair Jose ;
Poordad, Fred ;
Halota, Waldemar ;
Horsmans, Yves ;
Tsai, Naoky ;
Zhang, Hui ;
Tenney, Daniel J. ;
Tamez, Ricardo ;
Iloeje, Uchenna .
HEPATOLOGY, 2010, 51 (02) :422-430
123456