Chloride transport and the actions of nedocromil sodium and cromolyn sodium in asthma

被引：43

作者：

Alton, EWFW ^{[1
]}

Norris, AA ^{[1
]}

机构：

[1] FISONS PLC,LOUGHBOROUGH,LEICS,ENGLAND

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1996年 / 98卷 / 05期

基金：

英国惠康基金;

关键词：

chloride channel; cromolyn sodium; epithelial cell; mast cell; nedocromil sodium; neuronal activity;

D O I：

10.1016/S0091-6749(96)80136-9

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Nedocromil sodium has been shown to be capable of inhibiting chloride ion flux in mast cells, epithelial cells, and neurons. This feature may explain how ii can prevent responses such as mast-cell degranulation, the effects of osmolarity changes in the airways, and neuronal activation This mechanism may also provide a unifying hypothesis to explain the effects of nedocromil sodium on a range of cell types involved in asthma, such as sensory and efferent neurons and cells involved in inflammation.

引用

收藏

页码：S102 / S105

页数：4

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