Steroid-induced osteoporosis monitored by Raman spectroscopy

被引：2

作者：

Maher, Jason R. ^{[1
]}

Takahata, Masahiko ^{[2
]}

Awad, Hani A. ^{[2
]}

Berger, Andrew J. ^{[1
]}

机构：

[1] Univ Rochester, Inst Opt, Rochester, NY 14627 USA

[2] Univ Rochester, Ctr Med, Ctr Musculoskeletal Res, Rochester, NY 14627 USA

来源：

PHOTONIC THERAPEUTICS AND DIAGNOSTICS VII | 2011年 / 7883卷

关键词：

Raman spectroscopy; osteoporosis; rheumatoid arthritis; glucocorticoids; BONE;

D O I：

10.1117/12.873953

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Glucocorticoids are frequently used to treat inflammatory disorders such as rheumatoid arthritis. Unfortunately, extended exposure to this steroid is the leading cause of physician-induced osteoporosis, leaving patients susceptible to fractures at rates of 30-50%. In this presentation, we report correlations between Raman spectra and biomechanical strength tests on bones of glucocorticoid-and placebo-treated mice. Both wild-type mice and a transgenic model of rheumatoid arthritis have been studied. A two-way ANOVA model reveals statistically significant spectral differences as influenced by glucocorticoid treatment and mouse type.

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页数：7

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