Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis

被引：0
作者：
Zeisberg, Michael [1 ]
Kalluri, Raghu [1 ]
机构：
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div Matrix Biol, Boston, MA 02215 USA
来源：
FRONTIERS IN BIOSCIENCE | 2008年 / 13卷
关键词：
fibroblasts; epithelial-mesenchymal transition; EMT; bone morphogenic protein; BMP; chronic kidney disease; CKD; fibrosis; review;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Our current understanding of epithelial-mesenchymal transition (EMT) in the setting of tissue fibrosis is largely based on pioneering studies in the kidney. Evidence is emerging that EMT is a key component of chronic kidney disease, contributing to both destruction of the tubular epithelial compartment and accumulation of interstitial fibroblasts. While knowledge regarding EMT was previously based on experimental rodent studies, in recent years the evolving evidence demonstrates a role for EMT in human kidney diseases with chronic fibrosis.
引用
收藏
页码：6991 / 6998
页数：8
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