Analysis of Somatic Hypermutations of Immunoglobulin Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia

被引：0

作者：

Braoudaki, M. ^{[1
,2
]}

Katsibardi, K. ^{[2
]}

Giudicelli, V. ^{[3
]}

Karamolegou, K. ^{[2
]}

Papathanassiou, Ch. ^{[2
]}

Lefranc, M. -P. ^{[3
]}

Tzortzatou-Stathopoulou, F. ^{[1
,2
]}

机构：

[1] Univ Athens, Aghia Sophia Childrens Hosp, Univ Res Inst Study & Treatment Childhood Genet &, Dept Pediat 1,Hematol Oncol Unit, Goudi 11527, Greece

[2] Univ Athens, Aghia Sophia Childrens Hosp, Hematol Onol Unit, Dept Pediat 1, Athens 11527, Greece

[3] Univ Montpellier 2, Lab ImmunoGenet Mol LIGM, Inst Genet Humaine IGH, IMGT,UPR CNRS 1142, Montpellier, France

来源：

CANCER INVESTIGATION | 2011年 / 29卷 / 05期

关键词：

Somatic mutations; Immunoglobulin rearrangements; IMGT; Acute leukemia; CHRONIC LYMPHOCYTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; B-CELLS; DIVERSITY; DELETIONS; IG; REPERTOIRE; MECHANISMS; SELECTION; LYMPHOMA;

D O I：

10.3109/07357907.2011.584587

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The current study investigated the presence, frequency, and status of somatic hypermutations as well as their role in children with B lineage ALL. The obtained sequences were analyzed using IMGT/V-QUEST. Totally, 150 IGH sequences were evaluated; 139 from the 111 patients at the time of diagnosis and 11 from 8/111 patients at the time of relapse. The findings of the current report revealed the presence of somatically mutated V genes in childhood B lineage ALL. A higher frequency of somatic hypermutations was noted in unproductive rearrangements and was generally attributed to nucleotide mutation type, region, and IGHV gene subgroup biases.

引用

页码：360 / 364

页数：5

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