Rapid increase in Omicron infections in England during December 2021: REACT-1 study

被引：91

作者：

Elliott, Paul ^{[1
,2
,3
,4
,5
,6
]}

Bodinier, Barbara ^{[1
,2
]}

Eales, Oliver ^{[1
,7
,8
]}

Wang, Haowei ^{[1
,7
,8
]}

Haw, David ^{[1
,7
,8
]}

Elliott, Joshua ^{[3
,9
]}

Whitaker, Matthew ^{[1
,2
]}

Jonnerby, Jakob ^{[1
,10
]}

Tang, David ^{[1
,2
]}

Walters, Caroline E. ^{[1
,7
,8
]}

Atchison, Christina ^{[1
,3
]}

Diggle, Peter J. ^{[5
,11
]}

Page, Andrew J. ^{[12
]}

Trotter, Alexander J. ^{[12
]}

Ashby, Deborah ^{[1
]}

Barclay, Wendy ^{[9
]}

Taylor, Graham ^{[9
]}

Ward, Helen ^{[1
,3
,4
,7
,8
]}

Darzi, Ara ^{[3
,4
,13
]}

Cooke, Graham S. ^{[3
,4
,9
]}

Chadeau-Hyam, Marc ^{[1
,2
]}

Donnelly, Christl A. ^{[1
,7
,8
,14
]}

机构：

[1] Imperial Coll London, Sch Publ Hlth, London, England

[2] Imperial Coll London, MRC Ctr Environm & Hlth, Sch Publ Hlth, London, England

[3] Imperial Coll Healthcare NHS Trust, London, England

[4] Natl Inst Hlth Res Imperial Biomed Res Ctr, London, England

[5] Imperial Coll London, Hlth Data Res HDR UK, London, England

[6] Imperial Coll London, UK Dementia Res Inst, London, England

[7] Imperial Coll London, MRC Ctr Global Infect Dis Anal, London, England

[8] Imperial Coll London, Jameel Inst, London, England

[9] Imperial Coll London, Dept Infect Dis, London, England

[10] Imperial Coll Healthcare NHS Trust, Natl Heart & Lung Inst, London, England

[11] Univ Lancaster, Lancaster Med Sch, CHICAS, Lancaster, England

[12] Quadram Inst, Norwich, Norfolk, England

[13] Imperial Coll London, Inst Global Hlth Innovat, London, England

[14] Univ Oxford, Dept Stat, Oxford, England

来源：

SCIENCE | 2022年 / 375卷 / 6587期

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会; 欧盟地平线“2020”;

关键词：

D O I：

10.1126/science.abn8347

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The unprecedented rise in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed the prevalence of SARS-CoV-2 and its dynamics in England from the end of November to mid-December 2021 among almost 100,000 participants in the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, with an increasing proportion of infections due to Omicron. We observed large decreases in swab positivity among mostly vaccinated older children (12 to 17 years) relative to unvaccinated younger children (5 to 11 years), and in adults who received a third (booster) vaccine dose versus two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.

引用

页码：1406 / +

页数：23

共 20 条

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[9] Eales Oliver, 2021, Zenodo, DOI 10.5281/ZENODO.5574472
[10] Ferguson N, 2021, Report 50: Hospitalisation risk for Omicron cases in England

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