Redox and pH Dual-Responsive Supramolecular Micelles with a Traditional Polymer Block and a Supramolecular Block for Drug Controlled Release

被引：9
作者：
Zhang, Xiaojin [1 ]
Zhuo, Renxi [1 ]
机构：
[1] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2016年 / 217卷 / 17期
关键词：
cyclodextrin; host-guest interactions; micelles; pH-responsive; redox-responsive; COPOLYMER; DELIVERY; NANOPARTICLES; WATER; ASSEMBLIES; BEHAVIOR;
D O I：
10.1002/macp.201600172
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Redox and pH dual-responsive supramolecular micelles are prepared through a traditional polymer block and a supramolecular block to completely release the drugs. Ferrocene-introduced and hydrophobic-modified beta-cyclodextrin (beta-CD-Fc-Ace, where beta-CD, Fc, and Ace refer to beta-cyclodextrin, ferrocene, and acetal, respectively) is used to build the supramolecular block. Adamantane-terminated poly(ethylene glycol) methyl ether (mPEG-Ada) is the traditional polymer block. The average diameter of supramolecular micelles is approximate to 100 nm. Supramolecular micelles are able to control the release of the drugs in the cancer cells due to pH and redox microenvironments.
引用
收藏
页码：1926 / 1933
页数：8
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