Photocontrol of Contracting Muscle Fibers

被引：46

作者：

Hoppmann, Christian ^{[1
]}

Schmieder, Peter ^{[1
]}

Domaing, Petra ^{[3
]}

Vogelreiter, Gabriela ^{[1
]}

Eichhorst, Jenny ^{[1
]}

Wiesner, Burkhard ^{[1
]}

Morano, Ingo ^{[3
]}

Rueck-Braun, Karola ^{[2
]}

Beyermann, Michael ^{[1
]}

机构：

[1] Leibniz Inst Mol Pharmakol FMP, D-13125 Berlin, Germany

[2] Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany

[3] Max Delbruck Ctr Mol Med MDC, D-13125 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 33期

关键词：

azobenzene; inhibitors isomerization; nitric oxide; protein-protein interactions; NITRIC-OXIDE SYNTHASE; DUCHENNE MUSCULAR-DYSTROPHY; SKELETAL-MUSCLE; GLUTAMATE-RECEPTOR; AMINO-ACIDS; LIGHT; AZOBENZENE; SARCOLEMMA; CELLS; NNOS;

D O I：

10.1002/anie.201101398

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A twitch in time: Light-directed inhibition of the interaction between α-1-syntrophin and neuronal NO synthase (nNOS) in living skeletal muscle with a cell-permeable photoswitchable nNOS-derived peptide ligand results in photocontrol of muscle performance and nitric oxide signaling. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7699 / 7702

页数：4

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