Photocontrol of Contracting Muscle Fibers

被引：46
作者：
Hoppmann, Christian [1 ]
Schmieder, Peter [1 ]
Domaing, Petra [3 ]
Vogelreiter, Gabriela [1 ]
Eichhorst, Jenny [1 ]
Wiesner, Burkhard [1 ]
Morano, Ingo [3 ]
Rueck-Braun, Karola [2 ]
Beyermann, Michael [1 ]
机构：
[1] Leibniz Inst Mol Pharmakol FMP, D-13125 Berlin, Germany
[2] Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany
[3] Max Delbruck Ctr Mol Med MDC, D-13125 Berlin, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 33期
关键词：
azobenzene; inhibitors isomerization; nitric oxide; protein-protein interactions; NITRIC-OXIDE SYNTHASE; DUCHENNE MUSCULAR-DYSTROPHY; SKELETAL-MUSCLE; GLUTAMATE-RECEPTOR; AMINO-ACIDS; LIGHT; AZOBENZENE; SARCOLEMMA; CELLS; NNOS;
D O I：
10.1002/anie.201101398
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A twitch in time: Light-directed inhibition of the interaction between α-1-syntrophin and neuronal NO synthase (nNOS) in living skeletal muscle with a cell-permeable photoswitchable nNOS-derived peptide ligand results in photocontrol of muscle performance and nitric oxide signaling. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7699 / 7702
页数：4
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