Advances in assays of matrix metalloproteinases (MMPs) and their inhibitors

被引：19

作者：

Cheng, Xian-Chao ^{[1
]}

Fang, Hao ^{[1
]}

Xu, Wen-Fang ^{[1
]}

机构：

[1] Shandong Univ, Inst Med Chem, Sch Pharmaceut Sci, Jinan 250012, Peoples R China

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2008年 / 23卷 / 02期

关键词：

matrix metalloproteinases; inhibitors; assays;

D O I：

10.1080/14756360701511292

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Matrix metalloproteinases (MMPs) play an important role in many physiological and pathological processes. To assay the activities of MMPs is important in diagnosis and therapy of the MMPs associated diseases, such as neoplastic, rheumatic and cardiovascular diseases. Several assay systems have been developed, which include bioassay, zymography assay, immunoassay, fluorimetric assay, radio isotopic assay, phage-displayed assay, multiple-enzyme/multiple-reagent assay and activity-based profiling assay. The principle, application, advantage and disadvantage of these assays have been reviewed in this article.

引用

页码：154 / 167

页数：14

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