Lycium barbarum Polysaccharides as Antibiotic Substitutes Improve Growth Performance, Serum Immunity, Antioxidant Status, and Intestinal Health for Weaned Piglets

被引:15
作者
Yin, Yexin [1 ]
Wang, Fang [1 ]
Yang, Mei [1 ]
Tan, Bie [1 ]
Yin, Yulong [1 ,2 ]
Chen, Jiashun [1 ,2 ]
Yang, Zhe [1 ]
机构
[1] Hunan Agr Univ, Coll Anim Sci & Technol, Anim Nutrit Genome & Germplasm Innovat Res Ctr, Changsha, Peoples R China
[2] Chinese Acad Sci, Inst Subtrop Agr,Minist Agr, Hunan Prov Engn Res Ctr Healthy Livestock, Key Lab Agro ecol Processes Subtrop Region, Changsha, Peoples R China
基金
中国国家自然科学基金;
关键词
antioxidant; growth performance; immune; intestinal health; Lycium barbarum polysaccharides; weaned piglets; DIETARY SUPPLEMENTATION; CECAL MICROFLORA; BENZOIC-ACID; EXTRACT; PIGS; DIGESTIBILITY; PARAMETERS; QUALITY; SYSTEM; NRF2;
D O I
10.3389/fmicb.2021.819993
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The aim of the present study is to investigate the effects of dietary Lycium barbarum polysaccharides (LBPs) supplementation on the growth performance, immune response, serum antioxidant status, and intestinal health of weaned piglets. In total, 24 crossed healthy weaned piglets [Duroc x (Yorkshire x Landrace)], of similar body weight (7.47 +/- 0.22 kg), were randomly allocated to three treatment groups: CON (basal diet); LBPs (basal diet plus 4,000 mg/kg LBPs); and antibiotic (ABO, basal diet plus 20 mg/kg flavomycin and 50 mg/kg quinocetone). There were eight pigs per group. The study lasted 28 days. When compared with CON, LBPs or ABO dietary supplementation increased average daily gain (P < 0.05), decreased the ratio of feed to gain and the diarrhea ratio (P < 0.05). Similarly, when compared with CON, LBPs dietary supplementation increased serum immunoglobulin G, immunoglobulin M, interleukin-10, interleukin-2, and tumor necrosis factor-alpha levels (P < 0.05). Dietary LBPs enhanced the activity of serum total antioxidant capacity and glutathione peroxidase, and decreased malondialdehyde levels (P < 0.05). Principal component analysis showed a distinct separation between CON and LBPs groups, but no differences between ABO and LBPs groups. LBPs addition increased Lactobacillus and Faecalibacterium (P < 0.05) levels, while it decreased Enterococcaceae and Enterobacteriaceae (P < 0.05) levels. Furthermore, when compared with the CON group, LBPs increased villus height (P < 0.05) and the villus height to crypt depth ratio in the duodenum and jejunum (P < 0.05). Thus, dietary supplementation with LBPs improved growth performance, antioxidant capacity and immunity, regulated intestinal microbial composition, and may be used as an efficient antibiotic alternative in weaned piglet feed.
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页数:11
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