Synthesis and biological activity of pyrazino[3,2,1-j,k]carbazoles

被引：0
|
作者：
Shanmugasundaram, K [1 ]
Prasad, KJR [1 ]
机构：
[1] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1998年 / 37卷 / 11期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1-Oxo-1,2,3.4-tetrahydrocarbazole derivatives 1a-d have been reacted with ethanolamine to yield the respective ketimines 2a-d which on reduction with sodium borohydride furnish the corresponding amino derivatives 3a-d. The pyrazino[3,2,1-j,k]carbazole derivatives 4a-d are obtained by the cyclisation of 3a-d using ammonium chloride in diphenyl ether. Compounds 4a-d have been tested for their antimicrobial activity using chloramphenicol as a reference compound.
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页码：1133 / 1136
页数：4
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