Prenatal cocaine exposure and childhood obesity at nine years

被引:15
作者
LaGasse, Linda L. [1 ]
Gaskins, Ronnesia B. [1 ]
Bada, Henrietta S. [2 ]
Shankaran, Seetha [3 ]
Liu, Jing [1 ]
Lester, Barry M. [1 ]
Bauer, Charles R. [4 ]
Higgins, Rosemary D. [5 ]
Das, Abhik [6 ]
Roberts, Mary [1 ]
机构
[1] Brown Univ, Brown Ctr Study Children Risk, Warren Alpert Med Sch, Women & Infants Hosp Rhode Isl, Providence, RI 02905 USA
[2] Univ Kentucky Hosp, Lexington, KY USA
[3] Wayne State Univ, Dept Pediat, Detroit, MI 48202 USA
[4] Univ Miami, Miller Sch Med, Miami, FL 33136 USA
[5] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA
[6] RTI Int, Rockville, MD USA
关键词
Prenatal cocaine exposure; Prenatal alcohol exposure; Childhood obesity; Growth; Fetal origins; MATERNAL LIFE-STYLE; BODY-MASS INDEX; UNITED-STATES; SOCIOECONOMIC-STATUS; INTRAUTERINE GROWTH; BLOOD-PRESSURE; BIRTH-WEIGHT; RISK-FACTORS; MISSING DATA; OVERWEIGHT;
D O I
10.1016/j.ntt.2010.11.002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Little is known about the association between prenatal cocaine exposure and obesity. We tested whether prenatal cocaine exposure increases the likelihood of obesity in 561 9-year-old term children from the Maternal Lifestyle Study (MLS). Overall, 21.6% of children met criterion for obesity (body mass index [BMI]>= 95th percentile, age and sex-specific). While there was no overall cocaine effect on obesity, multivariate logistic analysis revealed that children exposed to cocaine but not alcohol were 4 times more likely to be obese (OR 4.11, CI 2.04-9.76) than children not exposed to either drug. No increase in obesity prevalence was found in children exposed to alcohol but not cocaine (OR 1.08, Cl .59-1.93) or both (OR 1.21, CI 0.66-2.22). Alcohol exposure may attenuate the effect of cocaine exposure on obesity. Increased obesity associated with cocaine but not alcohol exposure was first observed at 7 years. BMI was also elevated from 3 to 9 years in children exposed to cocaine but not alcohol, due to increasing weight but normal height. Prenatal exposure to cocaine may alter the neuroendocrine system and metabolic processes resulting in increased weight gain and childhood obesity. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:188 / 197
页数:10
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