Surface-enhanced Raman Probes Based on Gold Nanomaterials for in vivo Diagnosis and Imaging

Surface-enhanced Raman scattering (SERS) has received considerable attention from researchers due to its high molecular specificity, high sensitivity, non-invasiveness and multiplexing. Recently, various metal substrates have been exploited for SERS analysis and imaging. Among them, gold nanomaterials are important SERS substrates with outstanding surface plasmon resonance effects, structural adjustability and good biocompatibility, making them widely used in biomedical diagnosis and clinical fields. In this minireview, we discuss the latest progress about the application of gold-based nanomaterials as SERS probes in biomedical research, primarily for in vivo disease diagnosis and imaging. This review mainly includes the basic shapes and morphologies of gold based SERS probes, such as gold nanoparticles (AuNPs), gold nanorods (AuNRs), gold nanostars (AuNSs), as well as other gold nanostructures. Finally, a brief outlook for the future development of SERS technique in the context of efficient diagnostics and therapy guidance is provided. We hope that this review will facilitate the design and future development of surface-enhanced Raman probes based on gold nanomaterials.