The roles of transmembrane family proteins in the regulation of store-operated Ca2+ entry

被引:14
|
作者
Zhang, Ningxia [1 ]
Pan, Hongming [1 ]
Liang, Xiaojing [1 ]
Xie, Jiansheng [1 ,2 ]
Han, Weidong [1 ]
机构
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Med Oncol, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Inst Clin Sci,Lab Canc Biol, Hangzhou, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
Calcium; Ion channel gating; Store-operated channel; Ca2+ release-activated calcium channel; CRAC; ORAI1; STIM1; STING; SARAF; Membrane protein; Protein-protein interaction; ER-PM junction; INTERACTION MOLECULE-1 STIM1; TRIC-A; CALCIUM-ENTRY; CRAC CHANNELS; RYANODINE RECEPTOR; MEMBRANE-PROTEIN; FACTOR SARAF; K+-CHANNEL; ORAI1; RELEASE;
D O I
10.1007/s00018-021-04034-y
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Store-operated Ca2+ entry (SOCE) is a major pathway for calcium signaling, which regulates almost every biological process, involving cell proliferation, differentiation, movement and death. Stromal interaction molecule (STIM) and ORAI calcium release-activated calcium modulator (ORAI) are the two major proteins involved in SOCE. With the deepening of studies, more and more proteins are found to be able to regulate SOCE, among which the transmembrane (TMEM) family proteins are worth paying more attention. In addition, the ORAI proteins belong to the TMEM family themselves. As the name suggests, TMEM family is a type of proteins that spans biological membranes including plasma membrane and membrane of organelles. TMEM proteins are in a large family with more than 300 proteins that have been already identified, while the functional knowledge about the proteins is preliminary. In this review, we mainly summarized the TMEM proteins that are involved in SOCE, to better describe a picture of the interaction between STIM and ORAI proteins during SOCE and its downstream signaling pathways, as well as to provide an idea for the study of the TMEM family proteins.
引用
收藏
页数:13
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