Synthesis and antimycobacterial activity of alkyl 1-heteroaryl-1H-1,2,3-triazole-4-carboxylates.

被引：28

作者：

Japelj, B ^{[1
]}

Recnik, S ^{[1
]}

Cebasek, P ^{[1
]}

Stanovnik, B ^{[1
]}

Svete, J ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana 1000, Slovenia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 42卷 / 06期

关键词：

D O I：

10.1002/jhet.5570420620

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of alkyl 1-heteroaryl-1H-1,2,3-triazole-4-carboxylates 6a-u were synthesised in four steps from methyl (Z)-2-benzyloxycarbonylamino-3-(dimethylamino)prop-2-enoate (1) and heterocyclic amines 2a-s. Triazoles 6a-o were tested against antimycobacterial activity. For the most active compound, n-pentyl 1-(6-ph enylpyridazin-3-yl)-1H-1,2,3-triazole-4-carboxylate (6n), minimum inhibitory concentration 3.13 mu g/ml was determined.

引用

页码：1167 / 1173

页数：7

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