The IGF system

被引：146
作者：
Annunziata, Marta [1 ]
Granata, Riccarda [1 ]
Ghigo, Ezio [1 ]
机构：
[1] Univ Turin, Div Endocrinol Diabetol & Metab, Dept Internal Med, I-10126 Turin, Italy
来源：
ACTA DIABETOLOGICA | 2011年 / 48卷 / 01期
关键词：
IGF system; Cell proliferation; Insulin analogs; GROWTH-FACTOR-I; SMOOTH-MUSCLE-CELLS; BREAST-CANCER CELLS; REDUCES INSULIN REQUIREMENTS; SOMATOMEDIN-C; MITOGENIC POTENCY; RECEPTOR-BINDING; PLASMA-MEMBRANE; ANALOG GLARGINE; PROTEIN-KINASE;
D O I：
10.1007/s00592-010-0227-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The insulin-like growth factor (IGF) system plays essential role in the regulation of cell growth, proliferation and survival and affects nearly every organ system in the body. IGF-I, which has a high structural similarity to insulin, exerts growth-promoting effects, influences glucose metabolism and has neuroprotective and cardioprotective effects, partly because of its cell-proliferative and antiapoptotic properties. Aberrations in the IGF system may associate with various pathological conditions, including cancer. Insulin and its synthetic analogs are known to possess IGF-IR binding affinity, and concern has been raised about their mitogenic potential in humans. The present review summarizes the main aspects of the IGF system biology and the interactions among IGF-I, insulin, insulin analogs and their receptors.
引用
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页码：1 / 9
页数：9
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