Iridium-Catalyzed Intramolecular Enantioselective C-H Alkylation at the C-2 Position of N-Alkenylindoles

被引：68

作者：

Shibata, Takanori ^{[1
,2
]}

Ryu, Naoto ^{[1
]}

Takano, Hideaki ^{[1
]}

机构：

[1] Waseda Univ, Sch Adv Sci & Engn, Dept Chem & Biochem, Shinjuku Ku, Tokyo 1698555, Japan

[2] ACT C, JST, Kawaguchi, Saitama 3320012, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 06期

关键词：

alkylation; C-H activation; enantioselectivity; indoles; iridium catalysts; REVERSIBLE ALPHA-ELIMINATION; BOND ACTIVATION; ALLYLIC ALCOHOLS; INDOLES; ALKENES; FUNCTIONALIZATION; ARYL; HYDROHETEROARYLATION; HYDROARYLATION; IDENTIFICATION;

D O I：

10.1002/adsc.201401163

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Intramolecular enantioselective alkylation of N-alkenylindoles proceeded via C-H bond cleavage at the C-2 position in the presence of a cationic iridium catalyst with a diphosphine ligand. Aroyl groups at the C-3 position of the indoles operated as effective directing groups, and chiral 1-substituted-2,3-dihydro-1H-pyrrolo[1,2-a] indoles were obtained in high yield with excellent ee.

引用

页码：1131 / 1135

页数：5

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