Lead compounds discovered from libraries

被引：95
作者：
Golebiowski, A [1 ]
Klopfenstein, SR [1 ]
Portlock, DE [1 ]
机构：
[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 03期
关键词：
D O I：
10.1016/S1367-5931(00)00203-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lead compounds with the potential to progress to viable drug candidates have been identified from libraries using several strategies. These include rapid screening of large diverse collections, thematic libraries, project-directed libraries, and three-dimensional molecular models of corporate databases. There have been numerous success stories, including the identification of several clinical candidates.
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收藏
页码：273 / 284
页数：12
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