Where and when natriuretic peptides are secreted in the heart

被引：1
作者：
Korostyshevskaya, I. M. [1 ]
Maksimov, V. F. [1 ]
机构：
[1] Russian Acad Med Sci, Siberian Branch, Inst Physiol, Novosibirsk 630117, Russia
来源：
RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY | 2012年 / 43卷 / 03期
关键词：
natriuretic peptides; water-salt homeostasis; embryogenesis; heart; PRESSURE-INDEPENDENT ENHANCEMENT; CARDIAC-HYPERTROPHY; GENE-EXPRESSION; ATRIAL; FETAL; GRANULES; CHILDREN; FAILURE; HYPOXIA; PLASMA;
D O I：
10.1134/S1062360412030046
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This review presents recent data on the structure, synthesis, and secretion of cardiac natriuretic peptides. It is known that these hormones have a broad spectrum of activity, but they remain the least studied and poorly understood link in the regulation of the water-salt homeostasis. Emphasis is placed on the problem of ontogenetic formation of the heart secretory activity during embryogenesis. We discuss the available scarce and scattered information on the paracrine and autocrine effects of the peptides on intercellular interactions, and on the division, growth and differentiation of the heart cells. These issues are hardly addressed in Russian literature.
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页码：185 / 195
页数：11
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