Progress in the development of a diagnostic test for lung cancer through the analysis of breath volatiles

被引：14

作者：

Mazzone, Peter ^{[1
]}

机构：

[1] Cleveland Clin, Resp Inst, Cleveland, OH 44195 USA

来源：

JOURNAL OF BREATH RESEARCH | 2008年 / 2卷 / 03期

关键词：

D O I：

10.1088/1752-7155/2/3/037014

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In this paper I will describe some of the challenges faced in the management of lung cancer. I will describe the rationale for studying breath testing for volatile organic compounds as a diagnostic test for lung cancer, and outline the evidence that suggests the potential of this line of investigation. I will conclude by speculating about the progress that needs to occur for breath testing to become clinically useful, capable of meeting some of the challenges of this major public health problem.

引用

页数：6

共 21 条

[1] Computed tomography screening and lung cancer outcomes [J].

Bach, Peter B. ;

Jett, James R. ;

Pastorino, Ugo ;

Tockman, Melvyn S. ;

Swensen, Stephen J. ;

Begg, Colin B. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (09) :953-961

[2] A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis [J].

Chen, Xing ;

Xu, Fengjuan ;

Wang, Yule ;

Pan, Yuefeng ;

Lu, Deji ;

Wang, Ping ;

Ying, Kejing ;

Chen, Enguo ;

Zhang, Weimin .

CANCER, 2007, 110 (04) :835-844

[3] SMOKING AND LUNG-CANCER WITH SPECIAL REGARD TO TYPE OF SMOKING AND TYPE OF CANCER - A CASE-CONTROL STUDY IN NORTH SWEDEN [J].

DAMBER, LA ;

LARSSON, LG .

BRITISH JOURNAL OF CANCER, 1986, 53 (05) :673-681

[4] Determination of acetone in human breath by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization [J].

Deng, CH ;

Zhang, J ;

Yu, XF ;

Zhang, W ;

Zhang, XM .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 810 (02) :269-275

[5]

Goto I, 1996, CANCER RES, V56, P3725

[6]

Henschke CI, 2006, NEW ENGL J MED, V355, P1763, DOI 10.1056/NEJMoa060476

[7]

Ho JCM, 2001, CANCER RES, V61, P8578

[8] Cancer statistics, 2008 [J].

Jemal, Ahmedin ;

Siegel, Rebecca ;

Ward, Elizabeth ;

Hao, Yongping ;

Xu, Jiaquan ;

Murray, Taylor ;

Thun, Michael J. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2008, 58 (02) :71-96

[9] 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments [J].

Laderoute, Keith R. ;

Amin, Khalid ;

Calaoagan, Joy M. ;

Knapp, Merrill ;

Le, Theresamai ;

Orduna, Juan ;

Foretz, Marc ;

Viollet, Benoit .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (14) :5336-5347

[10] Detection of lung cancer by sensor array analyses of exhaled breath [J].

Machado, RF ;

Laskowski, D ;

Deffenderfer, O ;

Burch, T ;

Zheng, S ;

Mazzone, PJ ;

Mekhail, T ;

Jennings, C ;

Stoller, JK ;

Pyle, J ;

Duncan, J ;

Dweik, RA ;

Erzurum, SC .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (11) :1286-1291

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