In vitro activity of the novel antifungal compound F901318 against Australian Scedosporium and Lomentospora fungi

被引：61

作者：

Biswas, Chayanika ^{[1
]}

Law, Derek ^{[2
]}

Birch, Michael ^{[2
]}

Halliday, Catriona ^{[1
]}

Sorrell, Tania C. ^{[3
]}

Rex, John ^{[2
]}

Slavin, Monica ^{[4
,5
]}

Chen, Sharon C-A ^{[1
]}

机构：

[1] Westmead Hosp, New South Wales Hlth Pathol, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol Lab Serv, Sydney, NSW, Australia

[2] F2G Ltd, Manchester, Lancs, England

[3] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW, Australia

[4] Victorian Comprehens Canc Ctr, Melbourne, Vic, Australia

[5] Peter MacCallum Canc Ctr, Dept Infect Dis, Melbourne, Vic, Australia

来源：

MEDICAL MYCOLOGY | 2018年 / 56卷 / 08期

关键词：

Scedosporium; Lomentospora; antifungal susceptibility; F901318; orotomide; SUSCEPTIBILITY; ASPERGILLUS; FUSARIUM; VORICONAZOLE; GUIDELINES; AGENTS; MOLDS;

D O I：

10.1093/mmy/myx161

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We determined the in vitro activity of the novel orotomide antifungal, F901318, against 30 Lomentospora prolificans, 20 Scedosporium apiospermum, 7 S. aurantiacum, and 3 S. boydii, isolates in comparison with standard antifungals. Against L. prolificans, F901318 was the most potent compound (MIC90 0.25 mu g/ml); the geometric mean MIC (0.26 mu g/ml) was significantly lower (23-80-fold) than those of itraconazole, voriconazole, posaconazole, and isavuconazole (all P < .001), and amphotericin B (P < .05). F901318 also had good activity against S. apiospermum, S. aurantiacum, and S. boydii, comparable to that of voriconazole and posaconazole but was more active than isavuconazole for all three species.

引用

页码：1050 / 1054

页数：5

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