A concise asymmetric synthesis of (-)-rasfonin

被引：22
作者：
Huang, Yange [1 ]
Minnaard, Adriaan J. [1 ]
Feringa, Ben L. [1 ]
机构：
[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 01期
关键词：
CONTAINING NATURAL-PRODUCT; ABSOLUTE STEREOCHEMISTRY; CONJUGATE ADDITION; TT-1; RASFONIN; RAS; ACID; LOCALIZATION; EFFICIENT; SUBUNITS; FUNGUS;
D O I：
10.1039/c1ob06700a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A very efficient total synthesis of the apoptosis inducer (-)-rasfonin has been developed using CuBr/JosiPhos catalyzed iterative asymmetric conjugate addition of MeMgBr and Feringa's butenolide.
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收藏
页码：29 / 31
页数：3
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