Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system
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作者:
Goh, Eddy T. H.
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Univ Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Univ Dundee, Sir James Black Ctr, Scottish Inst Cell Signalling, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Goh, Eddy T. H.
[1
,2
]
Arthur, J. Simon C.
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Univ Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Univ Dundee, Sir James Black Ctr, Scottish Inst Cell Signalling, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Arthur, J. Simon C.
[1
,2
]
Cheung, Peter C. F.
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Nanyang Technol Univ, Singapore 637551, SingaporeUniv Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Cheung, Peter C. F.
[3
]
Akira, Shizuo
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Osaka Univ, WPI Immunol Frontier Ctr, Host Def Lab, Suita, Osaka 5650871, JapanUniv Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Akira, Shizuo
[4
]
Toth, Rachel
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Univ Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Univ Dundee, Sir James Black Ctr, Scottish Inst Cell Signalling, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Toth, Rachel
[1
,2
]
Cohen, Philip
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Univ Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Univ Dundee, Sir James Black Ctr, Scottish Inst Cell Signalling, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
Cohen, Philip
[1
,2
]
机构:
[1] Univ Dundee, Sir James Black Ctr, MRC Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
[2] Univ Dundee, Sir James Black Ctr, Scottish Inst Cell Signalling, Dundee DD1 5EH, Scotland
The E3 ubiquitin ligase Pellino 1 can be interconverted between inactive and active forms by a reversible phosphorylation mechanism. In vitro, phosphorylation and activation can be catalysed by either the IRAKs [IL (interleukin)-1-receptor-associated kinases] IRAK1 and IRAK4, or the IKK {I kappa B [inhibitor of NF-kappa B (nuclear factor kappa B)] kinase}-related kinases [IKK epsilon and TBK1 (TANK {TRAF [TNF (tumour-necrosis-factor)-receptor-associated factor]-associated NF-kappa B activator}-binding kinase 1)]. In the present study we establish that IRAK I is the major protein kinase that mediates the IL-1-stimulated activation of Pellino 1 in MEFs (mouse embryonic fibroblasts) or HEK (human embryonic kidney)-293 cells, whereas the IKK-related kinases activate Pellino 1 in TNF alpha-stimulated MEFs. The IKK-related kinases are also the major protein kinases that activate Pellino 1 in response to TLR (Toll-like receptor) ligands that signal via the adaptors MyD88 (myeloid differentiation primary response gene 88) and/or TRIF [TIR (Toll/IL-1 receptor) domain-containing adaptor protein inducing interferon beta]. The present studies demonstrate that, surprisingly, the ligands that signal via MyD88 do not always employ the same protein kinase to activate Pellino 1. Our results also establish that neither the catalytic activity of IRAK1 nor the activation of Pellino 1 is required for the initial transient activation of NF-kappa B and MAPKs (mitogen-activated protein kinases) that is triggered by IL-1 or TNF alpha in MEFs, or by TLR ligands in macrophages. The activation of Pellino 1 provides the first direct readout for IRAK1 catalytic activity in cells.
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页码:339 / 346
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BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
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Univ Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland
Clark, Kristopher
;
Takeuchi, Osamu
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Osaka Univ, Host Def Lab, World Premier Int Immunol Frontier Res Ctr, Suita, Osaka 5650871, JapanUniv Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland
Takeuchi, Osamu
;
Akira, Shizuo
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Osaka Univ, Host Def Lab, World Premier Int Immunol Frontier Res Ctr, Suita, Osaka 5650871, JapanUniv Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland
Akira, Shizuo
;
Cohen, Philip
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Univ Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland
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Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Clark, Kristopher
;
Peggie, Mark
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Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Peggie, Mark
;
Plater, Lorna
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Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Plater, Lorna
;
Sorcek, Ronald J.
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Boehringer Ingelheim Pharmaceut Inc, Dept Med Chem, Ridgefield, CT 06877 USAUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Sorcek, Ronald J.
;
Young, Erick R. R.
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Boehringer Ingelheim Pharmaceut Inc, Dept Med Chem, Ridgefield, CT 06877 USAUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Young, Erick R. R.
;
Madwed, Jeffrey B.
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Boehringer Ingelheim Pharmaceut Inc, Dept Cardiometab Dis Res, Ridgefield, CT 06877 USAUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Madwed, Jeffrey B.
;
Hough, Joanne
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MRC Technol, London NW7 1AD, EnglandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Hough, Joanne
;
McIver, Edward G.
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MRC Technol, London NW7 1AD, EnglandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
McIver, Edward G.
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Cohen, Philip
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Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
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Univ Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, Scotland
Clark, Kristopher
;
Plater, Lorna
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Univ Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, Scotland
Plater, Lorna
;
Peggie, Mark
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Univ Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, Scotland
Peggie, Mark
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Cohen, Philip
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Univ Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, Scotland
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
Handoyo, Hosea
;
Stafford, Margaret J.
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
Stafford, Margaret J.
;
McManus, Eamon
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
McManus, Eamon
;
Baltzis, Dionissios
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
Baltzis, Dionissios
;
Peggie, Mark
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
Peggie, Mark
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Cohen, Philip
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
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Univ Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland
Clark, Kristopher
;
Takeuchi, Osamu
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Osaka Univ, Host Def Lab, World Premier Int Immunol Frontier Res Ctr, Suita, Osaka 5650871, JapanUniv Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland
Takeuchi, Osamu
;
Akira, Shizuo
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Osaka Univ, Host Def Lab, World Premier Int Immunol Frontier Res Ctr, Suita, Osaka 5650871, JapanUniv Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland
Akira, Shizuo
;
Cohen, Philip
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Univ Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci,Sir James Black Ctr, Dundee DD1 5EH, Scotland
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Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Clark, Kristopher
;
Peggie, Mark
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Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Peggie, Mark
;
Plater, Lorna
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Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Plater, Lorna
;
Sorcek, Ronald J.
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h-index: 0
机构:
Boehringer Ingelheim Pharmaceut Inc, Dept Med Chem, Ridgefield, CT 06877 USAUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Sorcek, Ronald J.
;
Young, Erick R. R.
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机构:
Boehringer Ingelheim Pharmaceut Inc, Dept Med Chem, Ridgefield, CT 06877 USAUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Young, Erick R. R.
;
Madwed, Jeffrey B.
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h-index: 0
机构:
Boehringer Ingelheim Pharmaceut Inc, Dept Cardiometab Dis Res, Ridgefield, CT 06877 USAUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Madwed, Jeffrey B.
;
Hough, Joanne
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h-index: 0
机构:
MRC Technol, London NW7 1AD, EnglandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
Hough, Joanne
;
McIver, Edward G.
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h-index: 0
机构:
MRC Technol, London NW7 1AD, EnglandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
McIver, Edward G.
;
Cohen, Philip
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Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, MRC Prot Phosphorylat Unit, Sir James Black Ctr, Dundee DD1 5EH, Scotland
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Univ Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, Scotland
Clark, Kristopher
;
Plater, Lorna
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Univ Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, Scotland
Plater, Lorna
;
Peggie, Mark
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Univ Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, Scotland
Peggie, Mark
;
Cohen, Philip
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Univ Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, ScotlandUniv Dundee, Sir James Black Ctr, MRC, Prot Phosphorylat Unit,Coll Life Sci, Dundee DD1 5EH, Scotland
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
Handoyo, Hosea
;
Stafford, Margaret J.
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
Stafford, Margaret J.
;
McManus, Eamon
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
McManus, Eamon
;
Baltzis, Dionissios
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h-index: 0
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Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
Baltzis, Dionissios
;
Peggie, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland
Peggie, Mark
;
Cohen, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Univ Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, ScotlandUniv Dundee, Coll Life Sci, Sir James Black Ctr, Prot Phosphorylat Unit,MRC, Dundee DD1 5EH, Scotland