Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions

被引：64

作者：

Day, Rachael A. ^{[1
]}

Estabrook, Daniel A. ^{[1
]}

Logan, Jessica K. ^{[1
]}

Sletten, Ellen M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, 607 Charles E Young Dr E, Los Angeles, CA 90095 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 97期

关键词：

OXYGEN; HYPOXIA; NANOPARTICLES; RESISTANCE; PORPHYRIN; OVERCOME; CELLS;

D O I：

10.1039/c7cc07038a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photodynamic therapy (PDT) requires a photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and a photosensitizer. We find that the implementation of fluorous soluble photosensitizers enhances the efficacy of PDT.

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收藏

页码：13043 / 13046

页数：4

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