Cellular Uptake, Intracellular Trafficking and Biological Responses of Gold Nanoparticles

被引：14
|
作者：
Jiang, Xiu-Mei [1 ]
Wang, Li-Ming [1 ]
Chen, Chun-Ying [1 ]
机构：
[1] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2011年 / 58卷 / 03期
关键词：
GNPs; Uptake; Intracellular trafficking; Subcellular localization; Cellular response; Cytotoxicity; GENE-EXPRESSION; DRUG-DELIVERY; IN-VIVO; SURFACE; NANORODS; CELLS; SIZE; CYTOTOXICITY; TOXICITY; PROLIFERATION;
D O I：
10.1002/jccs.201190024
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Promising application of gold nanoparticles (GNPs) in biomedical and environmental fields is increasing the likelihood of direct interaction with living systems. The knowledge about GNPs interacting with cells is quite limited and however, is necessary for risk prediction and evaluation of biological effects. Herein, we review recent advances in cellular effects of GNPs including cellular uptake, trafficking, subcellular distribution and cellular responses, and the relationship between physiochemical properties of GNPs and biological effects as well. To uncover these issues, it is quite instructive for safe and sustainable use of GNPs.
引用
收藏
页码：273 / 281
页数：9
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