Peroxisome proliferator activated nuclear receptors: Possible role in the development of atherosclerosis

被引：0

作者：

Evdokimova, MA ^{[1
]}

Zateyshchikov, DA ^{[1
]}

Sidorenko, BA ^{[1
]}

机构：

[1] Presidential Med Ctr Russia, Moscow 121356, Russia

来源：

KARDIOLOGIYA | 2003年 / 43卷 / 11期

关键词：

peroxisome proliferator activated receptors; PPAR; atherosclerosis;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peroxisome proliferator activated nuclear receptors (PPAR) belong to steroid receptors and are represented by 3 types: PPARalpha, PPARbeta, PPARgamma. PPARalpha is a key regulator of fatty acid P-oxidation, participates in development of inflammatory reaction and atherosclerosis formation. Main effects of fibrates are mediated through PPARalpha activation. PPARgamma plays important role in lipid metabolism, processes of cell differentiation and growth, participates in glucose utilization and mechanisms of insulin resistance. Specific activators of PPARgamma are glytazones - a group of antidiabetic drugs. The role of PPARbeta in atherosclerosis formation has not been elucidated yet however results of some studies indicate participation of this receptor in atherosclerosis. Data of studies devoted to the role of PPARs and polymorphic markers of these receptors in the process of atherosclerosis are reviewed.

引用

页码：41 / 48

页数：8

共 45 条

[41] PPARγ induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPα during the conversion of 3T3 fibroblasts into adipocytes [J].