Physiological requirement of aldosterone action on the Na+/K+ pump in ADH-stimulated Na+ absorption in renal epithelium

被引：11
|
作者：
Marunaka, Y
机构：
[1] Division of Respiratory Research, Hosp. for Sick Children Res. Inst., University of Toronto, Toronto, Ont.
[2] Lab. for Cell. and Molec. Physiology, Division of Respiratory Research, Hospital for Sick Children, Toronto, Ont. M5G 1X8
来源：
JAPANESE JOURNAL OF PHYSIOLOGY | 1996年 / 46卷 / 04期
关键词：
antidiuretic hormone; distal nephron epithelium; A6; cells;
D O I：
10.2170/jjphysiol.46.357
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Short-circuit current measurement in renal epithelium (A6) indicated that the amount of antidiuretic hormone-stimulated Na+ entry in aldosterone-treated cells exceeded the ability of the Na+/K+-pump to extrude Na+ in aldosterone-untreated cells. This suggests that, if aldosterone has no stimulatory action on Na+/K+-pump activity, the activity of Na+/K+-pump is not large enough to extrude Na+ entering through antidiuretic hormone-activated Na+-permeant channels in the apical membrane. The present study concludes that the stimulatory action of aldosterone on the Na+/K+ pump is a physiological requirement in antidiuretic hormone-stimulated Na+ absorption.
引用
收藏
页码：357 / 361
页数：5
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