Physiological requirement of aldosterone action on the Na+/K+ pump in ADH-stimulated Na+ absorption in renal epithelium

被引：11
|
作者：
Marunaka, Y
机构：
[1] Division of Respiratory Research, Hosp. for Sick Children Res. Inst., University of Toronto, Toronto, Ont.
[2] Lab. for Cell. and Molec. Physiology, Division of Respiratory Research, Hospital for Sick Children, Toronto, Ont. M5G 1X8
来源：
JAPANESE JOURNAL OF PHYSIOLOGY | 1996年 / 46卷 / 04期
关键词：
antidiuretic hormone; distal nephron epithelium; A6; cells;
D O I：
10.2170/jjphysiol.46.357
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Short-circuit current measurement in renal epithelium (A6) indicated that the amount of antidiuretic hormone-stimulated Na+ entry in aldosterone-treated cells exceeded the ability of the Na+/K+-pump to extrude Na+ in aldosterone-untreated cells. This suggests that, if aldosterone has no stimulatory action on Na+/K+-pump activity, the activity of Na+/K+-pump is not large enough to extrude Na+ entering through antidiuretic hormone-activated Na+-permeant channels in the apical membrane. The present study concludes that the stimulatory action of aldosterone on the Na+/K+ pump is a physiological requirement in antidiuretic hormone-stimulated Na+ absorption.
引用
收藏
页码：357 / 361
页数：5
相关论文
共 50 条
  • [1] Kinetic contribution to extracellular Na+/K+ selectivity in the Na+/K+ pump
    Vleeskens, Elizabeth
    Clarke, Ronald J.
    FEBS OPEN BIO, 2018, 8 (05): : 854 - 859
  • [2] NA+ ABSORPTION IN APLYSIA INTESTINE - NA+ FLUXES AND INTRACELLULAR NA+ AND K+ ACTIVITIES
    GERENCSER, GA
    AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 244 (03): : R412 - R417
  • [3] Charge translocation by the Na+/K+ pump under Na+/Na+ exchange conditions:: Intracellular Na+ dependence
    Holmgren, M
    Rakowski, RF
    BIOPHYSICAL JOURNAL, 2006, 90 (05) : 1607 - 1616
  • [4] NUCLEOTIDE SPECIFICITY OF NA+ TRANSPORT AND OF ATPASE STIMULATED BY NA+ AND K+
    SCHONER, W
    BEUSCH, R
    KRAMER, R
    HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1968, 349 (01): : 14 - &
  • [5] DUAL ACTION OF ALDOSTERONE ON TOAD BLADDER - NA+ PERMEABILITY AND NA+ PUMP MODULATION
    PARK, CS
    EDELMAN, IS
    AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (04): : F517 - F525
  • [6] ERYTHROCYTE NA+,K+ COTRANSPORT AND NA+,K+ PUMP IN BLACK AND CAUCASIAN HYPERTENSIVE PATIENTS
    TUCK, ML
    GROSS, C
    MAXWELL, MH
    BRICKMAN, AS
    KRASNOSHTEIN, G
    MAYES, D
    HYPERTENSION, 1984, 6 (04) : 536 - 544
  • [7] CHARACTERIZATION OF THE ADIPOCYTE GHOST (NA+,K+) PUMP - INSIGHTS INTO THE INSULIN REGULATION OF THE ADIPOCYTE (NA+,K+) PUMP
    MCGILL, DL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (24) : 15817 - 15823
  • [8] CONTROL OF (NA+,K+)-ATPASE AND NA+ TRANSPORT BY OXYTOCIN AND ALDOSTERONE IN THE TOAD BLADDER
    GIRARDET, M
    GEERING, K
    ROSSIER, BC
    JOURNAL OF CELL BIOLOGY, 1983, 97 (05): : A162 - A162
  • [9] K+ DEPLETION AND NA+ PUMP DENSITY
    LAMB, JF
    AITON, JF
    OGDEN, P
    NATURE, 1982, 295 (5851) : 717 - 718
  • [10] The Na+,K+ pump and muscle excitability
    Clausen, T
    Nielsen, OB
    Harrison, AP
    Flatman, JA
    Overgaard, K
    ACTA PHYSIOLOGICA SCANDINAVICA, 1998, 162 (03): : 183 - 190
12345