Preparation and characterization of mesoporous magnetic MnFe2O4@mSiO2 nanocomposite for drug delivery application

Mesoporous magnetic nanocarriers have shown great potential for targeted drug delivery. Here, we have prepared mesoporous silica (mSiO(2)) and MnFe2O4 based magnetic nanocomposites (MnFe2O4@mSiO(2)) for biomedical application. MnFe2O4 nanoparticles were synthesized by two different methods viz. coprecipitation and thermal decomposition method and both were further incorporated in mSiO(2) by stober method. XRD, TEM and VSM results confirmed the formation of uniform, crystalline and superparamagnetic MnFe2O4 NPs (size 5-8 nm) and MnFe2O4@mSiO(2) nanocomposite (size 100-275 nm) for thermal decomposition method. Superparamagnetic MnFe2O4@mSiO(2) nanocomposite with discrete nature, spherical shape and suitable particle size could have potential applications in targeted drug delivery. (C) 2018 Elsevier Ltd. Peer-review under responsibility of the scientific committee of the International Conference on Nano Science & Engineering Application (ICONSEA-2018) Centre for Nano Science and Technology, ICONSEA-2018.