GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

被引：2

作者：

Demetriades, Constantinos ^{[1
,2
]}

Nuechel, Julian ^{[1
]}

Plomann, Markus ^{[3
,4
]}

机构：

[1] Max Planck Inst Biol Ageing MPI AGE, D-50931 Cologne, Germany

[2] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50931 Cologne, Germany

[3] Univ Cologne, Fac Med, D-50931 Cologne, Germany

[4] Univ Hosp Cologne, Ctr Biochem, D-50931 Cologne, Germany

来源：

CELL STRESS | 2021年 / 5卷 / 11期

基金：

欧洲研究理事会;

关键词：

D O I：

10.15698/cst2021.11.259

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity of signaling pathways, and interact with their environment by qualitatively and quantitatively modifying their intracellular, surface, and extracellular proteomes. How this delicate communication takes place is a hot topic in cell biological research, and has important implications for human disease.

引用

页码：173 / 175

页数：3