The biology and future prospects of antivirulence therapies

被引：624

作者：

Cegelski, Lynette ^{[1
]}

Marshall, Garland R. ^{[2
,3
]}

Eldridge, Gary R. ^{[4
]}

Hultgren, Scott J. ^{[1
]}

机构：

[1] Washington Univ, Dept Mol Microbiol, St Louis, MO 63110 USA

[2] Washington Univ, Ctr Computat Biol, St Louis, MO 63110 USA

[3] Washington Univ, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA

[4] Sequoia Sci, St Louis, MO 63114 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 01期

关键词：

D O I：

10.1038/nrmicro1818

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics demand the discovery of new therapeutic approaches. Targeting bacterial virulence is an alternative approach to antimicrobial therapy that offers promising opportunities to inhibit pathogenesis and its consequences without placing immediate life-or-death pressure on the target bacterium. Certain virulence factors have been shown to be potential targets for drug design and therapeutic intervention, whereas new insights are crucial for exploiting others. Targeting virulence represents a new paradigm to empower the clinician to prevent and treat infectious diseases.

引用

页码：17 / 27

页数：11

共 101 条

[1]

Acharya V N, 1992, J Postgrad Med, V38, P52

[2] Molecular mechanisms of antibacterial multidrug resistance [J].

Alekshun, Michael N. ;

Levy, Stuart B. .

CELL, 2007, 128 (06) :1037-1050

[3] Intracellular bacterial biofilm-like pods in urinary tract infections [J].

Anderson, GG ;

Palermo, JJ ;

Schilling, JD ;

Roth, R ;

Heuser, J ;

Hultgren, SJ .

SCIENCE, 2003, 301 (5629) :105-107

[4] Human botulism immune globulin for the treatment of infant botulism [J].

Arnon, SS ;

Schechter, R ;

Maslanka, SE ;

Jewell, NP ;

Hatheway, CL .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (05) :462-471

[5] THE VANS-VANR 2-COMPONENT REGULATORY SYSTEM CONTROLS SYNTHESIS OF DEPSIPEPTIDE PEPTIDOGLYCAN PRECURSORS IN ENTEROCOCCUS-FAECIUM BM4147 [J].

ARTHUR, M ;

MOLINAS, C ;

COURVALIN, P .

JOURNAL OF BACTERIOLOGY, 1992, 174 (08) :2582-2591

[6] The gut microbiota as an environmental factor that regulates fat storage [J].

Bäckhed, F ;

Ding, H ;

Wang, T ;

Hooper, LV ;

Koh, GY ;

Nagy, A ;

Semenkovich, CF ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723

[7] Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle [J].

Bailey, Leslie ;

Gylfe, Asa ;

Sundin, Charlotta ;

Muschiol, Sandra ;

Elofsson, Mikael ;

Nordstrom, Peter ;

Henriques-Normark, Birgitta ;

Lugert, Raimond ;

Waldenstrom, Anders ;

Wolf-Watz, Hans ;

Bergstrom, Sven .

FEBS LETTERS, 2007, 581 (04) :587-595

[8] A pneumococcal pilus influences virulence and host inflammatory responses [J].

Barocchi, MA ;

Rie, J ;

Zogaj, X ;

Hemsley, C ;

Albiger, B ;

Kanth, A ;

Dahlberg, S ;

Fernebro, J ;

Moschioni, M ;

Masignani, V ;

Hultenby, K ;

Taddei, AR ;

Beiter, K ;

Wartha, F ;

von Euler, A ;

Covacci, A ;

Holden, DW ;

Normark, S ;

Rappuoli, R ;

Henriques-Normark, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2857-2862

[9] Two-component signal transduction as a target for microbial anti-infective therapy [J].

Barrett, JF ;

Hoch, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) :1529-1536

[10] Bacterially speaking [J].

Bassler, BL ;

Losick, R .

CELL, 2006, 125 (02) :237-246

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