Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

被引：98
作者：
Chen, Bendong [1 ,2 ]
Ning, Mingliang [3 ]
Yang, Guangshun [1 ]
机构：
[1] Second Mil Med Univ, Eastern Hepatobiliary Hosp, Dept Hepat Surg 5, Shanghai 200438, Peoples R China
[2] Ningxia Med Univ, Gen Hosp, Dept Hepatobiliary Surg, Yinchuan 750004, Peoples R China
[3] Ningxia Med Univ, Gen Hosp, Dept Surg Oncol, Yinchuan 750004, Peoples R China
来源：
MOLECULES | 2012年 / 17卷 / 04期
关键词：
hepatocellular carcinoma; paeonol; oxidative injury; immunity; diethyl-nitrosamine; GLUTATHIONE-PEROXIDASE; OXIDATIVE STRESS; LIVER; ENZYMES; QUERCETIN; BLOOD; CELLS; LUNG; HEPATOCARCINOGENESIS; DIETHYLNITROSAMINE;
D O I：
10.3390/molecules17044672
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-alpha and IFN-gamma and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
引用
收藏
页码：4672 / 4683
页数：12
相关论文
共 53 条
[11]   NF-κB and TNF-α:: A positive autocrine loop in human lung mast cells? [J].
Coward, WR ;
Okayama, Y ;
Sagara, H ;
Wilson, SJ ;
Holgate, ST ;
Church, MK .
JOURNAL OF IMMUNOLOGY, 2002, 169 (09) :5287-5293
[12]   Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis [J].
Cruz-Correa, Marcia ;
Shoskes, Daniel A. ;
Sanchez, Patricia ;
Zhao, Rhongua ;
Hylind, Linda M. ;
Wexner, Steven D. ;
Giardiello, Francis M. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (08) :1035-1038
[13]   Involvement of oxidative stress in hepatocellular tumor-promoting activity of oxfendazole in rats [J].
Dewa, Yasuaki ;
Nishimura, Jihei ;
Muguruma, Masako ;
Jin, Meilan ;
Kawai, Masaomi ;
Saegusa, Yukie ;
Okamura, Toshiya ;
Umemura, Takashi ;
Mitsumori, Kunitoshi .
ARCHIVES OF TOXICOLOGY, 2009, 83 (05) :503-511
[14]   Floxuridine coupling with lactosaminated human albumin to increase drug efficacy on liver micrometastases [J].
Di Stefano, G ;
Busi, C ;
Fiume, L .
DIGESTIVE AND LIVER DISEASE, 2002, 34 (06) :439-446
[15]   Running exercise may reduce risk for lung and liver cancer by inducing activity of antioxidant and phase II enzymes [J].
Duncan, K ;
Harris, S ;
Ardies, CM .
CANCER LETTERS, 1997, 116 (02) :151-158
[16]   Quercetin reduces blood pressure in hypertensive subjects [J].
Edwards, Randi L. ;
Lyon, Tiffany ;
Litwin, Sheldon E. ;
Rabovsky, Alexander ;
Symons, J. David ;
Jalili, Thunder .
JOURNAL OF NUTRITION, 2007, 137 (11) :2405-2411
[17]   TISSUE SULFHYDRYL GROUPS [J].
ELLMAN, GL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77
[18]   Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-κB and AP-1 [J].
Farombi, Ebenezer O. ;
Shrotriya, Sangeeta ;
Surh, Young-Joon .
LIFE SCIENCES, 2009, 84 (5-6) :149-155
[19]  
Gayathri R, 2009, ASIAN PAC J CANCER P, V10, P933
[20]   The effects of diazinon on pancreatic damage and ameliorating role of vitamin E and vitamin C [J].
Gokalp, O ;
Buyukvanli, B ;
Cicek, E ;
Ozer, MK ;
Koyu, A ;
Altuntas, I ;
Koylu, H .
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2005, 81 (02) :123-128
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