Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

被引：98
作者：
Chen, Bendong [1 ,2 ]
Ning, Mingliang [3 ]
Yang, Guangshun [1 ]
机构：
[1] Second Mil Med Univ, Eastern Hepatobiliary Hosp, Dept Hepat Surg 5, Shanghai 200438, Peoples R China
[2] Ningxia Med Univ, Gen Hosp, Dept Hepatobiliary Surg, Yinchuan 750004, Peoples R China
[3] Ningxia Med Univ, Gen Hosp, Dept Surg Oncol, Yinchuan 750004, Peoples R China
来源：
MOLECULES | 2012年 / 17卷 / 04期
关键词：
hepatocellular carcinoma; paeonol; oxidative injury; immunity; diethyl-nitrosamine; GLUTATHIONE-PEROXIDASE; OXIDATIVE STRESS; LIVER; ENZYMES; QUERCETIN; BLOOD; CELLS; LUNG; HEPATOCARCINOGENESIS; DIETHYLNITROSAMINE;
D O I：
10.3390/molecules17044672
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-alpha and IFN-gamma and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
引用
收藏
页码：4672 / 4683
页数：12
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