Serum inhibin pro αC in infertile men

被引：1

作者：

Fujisawa, M ^{[1
]}

Yamazaki, T ^{[1
]}

Dobashi, M ^{[1
]}

Okada, H ^{[1
]}

Kamidono, S ^{[1
]}

机构：

[1] Kobe Univ, Sch Med, Dept Urol, Kobe, Hyogo 650, Japan

来源：

ARCHIVES OF ANDROLOGY | 2001年 / 47卷 / 03期

关键词：

infertile men; inhibin A; inhibin B; inhibin pro alpha C;

D O I：

10.1080/014850101753145898

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Specific assays have been developed for bioactive inhibin dimers, inhibin A and B, and inhibin alpha-subunit Precursor pro alphaC. To better understand the role of serum inhibin pro alphaC in infertile men, the authors measured these forms of inhibin in sera from 39 infertile men and analyzed inhibin relationships with serum gonadotropins, testosterone, and estradiol. All subjects had oligozoospermia. Inhibin A levels were undetectable in all subjects. Inhibin B concentrations were 117 +/- 59 pg/mL. Inhibit B concentrations correlated negatively with serum FSH (r = .584, p < .0001) and positively with sperm count (p < .01) and bilateral testicular volume (r = .607, p < .0001). The concentration of pro alphaC was 556 +/- 236 pg/mL (normal range, 446 +/- 28). Inhibin pro alphaC showed no correlation with ser-um FSH, LH, testosterone, sperm concentration, and bilateral testicular volume. In addition, inhibin pro alphaC was not correlated with inhibin B. Pro alphaC is unlikely to be a useful marker for spermatogenesis in infertile men compared with inhibin B.

引用

页码：191 / 194

页数：4

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