Synthesis of New Dopamine D1 Antagonist SCH 23390 Analogues by the Stereoselective Stevens Rearrangement

被引：13

作者：

Ariza, Manuela ^{[1
]}

Diaz, Amelia ^{[1
]}

Suau, Rafael ^{[1
]}

Valpuesta, Maria ^{[1
]}

机构：

[1] Univ Malaga, Fac Ciencias, Dept Quim Organ, E-29071 Malaga, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 32期

关键词：

Medicinal chemistry; Nitrogen heterocycles; Rearrangement; Ylides; Stereoselectivity; RECEPTOR ANTAGONIST; DISCOVERY; ECOPIPAM; POTENT; TETRAHYDROISOQUINOLINE; ISOQUINOLINE; ALKALOIDS; SCH-23390; DISEASE; BINDING;

D O I：

10.1002/ejoc.201100991

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis for new SCH 23390 analogues bearing different substituents at the C-1 position has been developed by using the diastereoselective Stevens rearrangement. This procedure has provided a good number of new 1,2-disubstituted 1H-3-benzazepines, either through isolation of the isoquinolinium salts or directly by using a new one-pot N-alkylation-Stevens rearrangement reaction.

引用

页码：6507 / 6518

页数：12

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