In vitro activity of the essential oil of Origanum vulgare against Sporothrix schenckii

被引：12
作者：
Cleff, M. B. [1 ]
Meinerz, A. R. M. [1 ]
Schuch, L. F. D. [1 ]
Rodrigues, M. R. A. [2 ]
Meireles, M. C. A. [2 ]
Mello, J. R. B. [1 ]
机构：
[1] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil
[2] Univ Fed Pelotas, Pelotas, RS, Brazil
来源：
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA | 2008年 / 60卷 / 02期
关键词：
Sporothrix schenckii; Origanum vulgare; oregano; treatment;
D O I：
10.1590/S0102-09352008000200039
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
In vitro activity of the essential oil Origanum vulgare against Sporothrix schenckii was determined by the MIC (Minimum Inhibitory Concentration). For this, seven samples of S. schenckii were studied, two isolated from two cases of human sporotrichosis and five isolated from cats. Analysis of the essential oil was carried out in a gas chromatograph (GC/ FID) for the identification and quantification of thymol and carvacrol (antifungal agents). MIC was obtained based on the microdilution method according to the adapted document NCCLS-M 27A2 for fitopharmacy. All the isolates presented sensibility to the essential oil. S. schenckii was inhibited in a concentration of 0.25% (250 mu l/ml). Chromatographic analysis showed that thymol concentration was bigger than carvacrol. The antifungal activity demonstrated by the essential oil of O. vulgare against S. Schenckii stimulates the accomplishment of more studies, including in vivo studies.
引用
收藏
页码：513 / 516
页数：4
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