New Applications of Photodynamic Therapy in the Management of Candidiasis

被引：31

作者：

Rodriguez-Cerdeira, Carmen ^{[1
,2
,3
,4
,5
]}

Martinez-Herrera, Erick ^{[1
,4
,5
,6
,7
]}

Fabbrocini, Gabriella ^{[4
,8
]}

Sanchez-Blanco, Beatriz ^{[1
,3
,4
]}

Lopez-Barcenas, Adriana ^{[4
,5
,9
]}

EL-Samahy, May ^{[4
,10
]}

Juarez-Duran, Eder R. ^{[1
,5
,9
]}

Gonzalez-Cespon, Jose Luis ^{[1
,3
]}

机构：

[1] UVIGO, SERGAS, Hlth Res Inst, Efficiency Qual & Costs Hlth Serv Res Grp EFISALU, Vigo 36213, Spain

[2] Hosp Vithas Ntra Sra Fatima, Dermatol Dept, Vigo 36206, Spain

[3] Univ Vigo, Campus Vigo, Vigo 36310, Spain

[4] European Womens Dermatol & Venereol Soc EWDVS, Tui 36700, Spain

[5] Psychodermatol Task Force Ibero Latin Amer Coll D, RA-2019 Buenos Aires, DF, Argentina

[6] Reg Hosp High Specialty Ixtapaluca, Res Unit, Ixtapaluca 56530, Mexico

[7] Natl Polytech Inst, Higher Sch Med, Postgrad Studies & Res Sect, Mexico City 07340, DF, Mexico

[8] Univ Naples Federico II, Dept Dermatol, I-80138 Naples, Italy

[9] Manuel Gea Gonzalez Hosp, Sect Mycol, Dermatol Dept, Mexico City 14080, DF, Mexico

[10] Univ Med, Dept Dermatol, Cairo 11591, Egypt

来源：

JOURNAL OF FUNGI | 2021年 / 7卷 / 12期

关键词：

photosensitizer; nanocarriers; Candida spp; genes; antimicrobial photodynamic therapy; PORPHYRIN-BASED THERANOSTICS; GENE-EXPRESSION; METHYLENE-BLUE; ALBICANS; PHOTOSENSITIZERS; INACTIVATION; DENDRIMERS; EFFICACY;

D O I：

10.3390/jof7121025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The most important aetiological agent of opportunistic mycoses worldwide is Candida spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of Candida albicans occur with greater frequency and variable resistance patterns. Photodynamic therapy (PDT) has been recognised as an alternative treatment to kill pathogenic microorganisms. PDT utilises a photosensitizer, which is activated at a specific wavelength and oxygen concentration. Their reaction yields reactive oxygen species that kill the infectious microorganism. A systematic review of new applications of PDT in the management of candidiasis was performed. Of the 222 studies selected for in-depth screening, 84 were included in this study. All the studies reported the antifungal effectiveness, toxicity and dosimetry of treatment with antimicrobial PDT (aPDT) with different photosensitizers against Candida spp. The manuscripts that are discussed reveal the breadth of the new applications of aPDT against Candida spp., which are resistant to common antifungals. aPDT has superior performance compared to conventional antifungal therapies. With further studies, aPDT should prove valuable in daily clinical practice.

引用

页数：28

共 85 条

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