Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii

被引：10

作者：

Brandao, Geane P. ^{[1
]}

Melo, Maria N. ^{[1
]}

Caetano, Braulia C. ^{[2
]}

Carneiro, Claudia M. ^{[3
]}

Silva, Leticia A. ^{[1
]}

Vitor, Ricardo W. A. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Ouro Preto, Inst Ciencias Biol & Exatas, Ouro Preto, MG, Brazil

来源：

EXPERIMENTAL PARASITOLOGY | 2011年 / 128卷 / 04期

关键词：

Experimental toxoplasmosis; Re-infection; Recombinant strains; C57BL/6; BALB/c; CONGENITAL TOXOPLASMOSIS; IFN-GAMMA; IDENTIFICATION; ENCEPHALITIS; RESISTANCE; INFECTION; CELLS; GENE; MHC;

D O I：

10.1016/j.exppara.2011.05.015

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

This work reports results of re-infection of BALB/c and C57BL/6 mice with different recombinant strains of Toxoplasma gondii. Mice were prime-infected with the non-virulent D8 strain and challenged with virulent strains. PCR-RFLP of cS 10-A6 genetic marker of T. gondii demonstrated that BALB/c mice were reinfected with the EGS strain, while C57BL/6 mice were re-infected with the EGS and CH3 strains. Levels of IFN-gamma and IL-10 after D8 prime-infection were lower in C57BL/6 than in BALB/c mice. Brain inflammation after D8 prime-infection was more intense in C57BL/6 than in BALB/c mice. It was shown that reinfection depends on mice lineage and genotype of the strain used in the challenge. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：433 / 437

页数：5

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