FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

被引：0
|
作者：
Wehrens, XH
Lehnart, SE
Huang, F
Vest, JA
Reiken, SR
Mohler, PJ
Sun, J
Guatimosim, S
Song, LS
Rosemblit, N
d'Armiento, JM
Napolitano, C
Memmi, M
Maugeri, FS
Priori, SG
Maugeri, FS
Lederer, JW
Marks, AR
机构：
[1] Columbia Univ, New York, NY USA
[2] Duke Univ, Ctr Med, Durham, NC USA
[3] Univ Maryland, Biotechnol Inst, Baltimore, MD USA
[4] Fondaz S Maugeri, Pavia, Italy
来源：
CIRCULATION | 2003年 / 108卷 / 17期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
704
引用
收藏
页码：149 / 149
页数：1
相关论文
共 35 条
  • [11] Low dose of propranolol prevents the development of heart failure by restoring the defective interaction of FKBP12.6 with cardiac ryanodine receptor
    Doi, M
    Yano, M
    Kobayashi, S
    Kohno, M
    Suetsugu, M
    Tokuhisa, T
    Okuda, S
    Ohkusa, T
    Kohno, M
    Matsuzaki, M
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (05) : 165A - 165A
  • [12] The FKBP12.6 isoform is selectively associated with cardiac calcium release channel (CRC) from diverse animals.
    Qi, Y
    Murray, K
    Fleischer, S
    BIOPHYSICAL JOURNAL, 1997, 72 (02) : TH165 - TH165
  • [13] Identification of novel missense mutations of cardiac ryanodine receptor gene in exercise-induced sudden death at autopsy
    Creighton, W
    Virmani, R
    Kutys, R
    Burke, A
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2006, 8 (01): : 62 - 67
  • [14] Defective regulation of the cardiac calcium release channel/ryanodine receptor in failing hearts
    Marks, AR
    Marx, SO
    Reiken, S
    Rosemblit, N
    BIOPHYSICAL JOURNAL, 2000, 78 (01) : 16A - 16A
  • [15] Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias
    Xiao, Jianmin
    Tian, Xixi
    Jones, Peter P.
    Bolstad, Jeff
    Kong, Huihui
    Wang, Ruiwu
    Zhang, Lin
    Duff, Henry J.
    Gillis, Anne M.
    Fleischer, Sidney
    Kotlikoff, Michael
    Copello, Julio A.
    Chen, S. R. Wayne
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (48) : 34828 - 34838
  • [16] Protein kinase A phosphorylation at serine-2808 of the cardiac Ca2+-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6)
    Xiao, BL
    Sutherland, C
    Walsh, MP
    Chen, SRW
    CIRCULATION RESEARCH, 2004, 94 (04) : 487 - 495
  • [17] Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor)
    Masumiya, H
    Wang, RW
    Zhang, J
    Xiao, BL
    Chen, SRW
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (06) : 3786 - 3792
  • [18] FKBP12.6-mediated stabilization of calcium release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure
    Yano, M
    Kobayashi, S
    Kohno, M
    Doi, M
    Okuda, S
    Tokuhisa, T
    Suetsugu, M
    Ohkusa, T
    CIRCULATION, 2002, 106 (19) : 224 - 224
  • [19] Cellular mechanisms of exercise-induced sudden cardiac death linked to mutations in calsequestrin
    Terentyev, D
    Viatchenko-Karpinski, S
    Gyorke, I
    Volpe, P
    Williams, SC
    Gyorke, S
    CIRCULATION, 2003, 108 (17) : 181 - 181
  • [20] FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure
    Yano, M
    Kobayashi, S
    Kohno, M
    Doi, M
    Tokuhisa, T
    Okuda, S
    Suetsugu, M
    Hisaoka, T
    Obayashi, M
    Ohkusa, T
    Kohno, M
    Matsuzaki, M
    CIRCULATION, 2003, 107 (03) : 477 - 484
1234