Safe and Selective Nitro Group Reductions Catalyzed by Sustainable and Recyclable Fe/ppm Pd Nanoparticles in Water at Room Temperature

被引：143

作者：

Feng, Jie ^{[1
,2
]}

Handa, Sachin ^{[1
]}

Gallou, Fabrice ^{[3
]}

Lipshutz, Bruce H. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[2] Nanjing Univ Sci & Technol, Coll Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

[3] Novartis Pharmaceut, Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 31期

关键词：

green chemistry; micelles; nanoparticles; reduction; water chemistry; CROSS-COUPLINGS; PALLADIUM-NANOPARTICLE; AROMATIC-AMINES; NITROARENES; HYDROGENATION; COMPLEXES; EFFICIENT; ANILINES; DESIGN; ETHERS;

D O I：

10.1002/anie.201604026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As a result of a unique synergy between ligand-free Fe/ppm Pd nanoparticles and PEG-containing designer surfactants, a facile and selective reduction of nitro-containing aromatics and heteroaromatics can be effected in water at room temperature in the presence of NaBH4. This new nanotechnology involves low catalyst loadings, is highly chemoselective, and tolerates a wide variety of functional groups. The process, which includes recycling of the entire aqueous medium, offers a general, environmentally responsible, and notably safe approach to highly valued reductions of nitro-containing compounds.

引用

页码：8979 / 8983

页数：5

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